Pulmonary fibrosis with predominant CD8 lymphocytic alveolitis and anti-Jo-1 antibodies

Details

Serval ID
serval:BIB_0A99D986AFA6
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Pulmonary fibrosis with predominant CD8 lymphocytic alveolitis and anti-Jo-1 antibodies
Journal
European Respiratory Journal
Author(s)
Sauty  A., Rochat  T., Schoch  O. D., Hamacher  J., Kurt  A. M., Dayer  J. M., Nicod  L. P.
ISSN
0903-1936 (Print)
Publication state
Published
Issued date
12/1997
Volume
10
Number
12
Pages
2907-12
Notes
Case Reports
Journal Article --- Old month value: Dec
Abstract
Interstitial lung disease (ILD) is a complication of polymyositis (PM) and dermatomyositis (DM). It often manifests itself in association with myositis-specific antisynthetase autoantibodies, among which anti-Jo-1 antibodies are the most commonly encountered. In contrast, ILD associated with anti-Jo-1 antibodies without muscle involvement is rare and not well characterized. We report four patients presenting with ILD associated with anti-Jo-1 antibodies. Histological findings of transbronchial biopsies disclosed a pattern consistent with nonspecific interstitial pneumonitis, a CD8+ lymphocytosis was found in bronchoalveolar lavage. Only one of these patients developed an "antisynthetase syndrome" with PM, after nearly 2 yrs of severe ILD. The clinical conditions of all four cases showed stabilization or improvement when cyclosporine was added to their immunosuppressive treatment. These cases confirm that a CD8+ lymphocytic interstitial lung disease may be the first, and sole manifestation of autoimmune disease associated with anti-Jo-1 antibodies. Furthermore, they suggest that this form of interstitial lung disease apparently has a poor response to steroids and cytotoxic drugs, but may respond to moderate doses of cyclosporine and azathioprine in addition to low doses of steroids.
Keywords
Aged Antibodies, Antinuclear/*analysis Autoantibodies/analysis Azathioprine/therapeutic use Biopsy, Needle Bronchoalveolar Lavage Fluid/cytology CD8-Positive T-Lymphocytes/*immunology Cyclosporins/therapeutic use Drug Therapy, Combination Female Humans Immunosuppressive Agents/therapeutic use Lung Diseases, Interstitial/diagnosis/drug therapy/*immunology Lymphocyte Count Male Middle Aged Pulmonary Fibrosis/diagnosis/drug therapy/*immunology Steroids/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:52
Last modification date
20/08/2019 12:32
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