Functional multiparametric magnetic resonance imaging of the kidneys using blood oxygen level dependent and diffusion-weighted sequences.

Details

Serval ID
serval:BIB_0A6B71517B54
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional multiparametric magnetic resonance imaging of the kidneys using blood oxygen level dependent and diffusion-weighted sequences.
Journal
The Journal of urology
Author(s)
Giannarini G., Kessler T.M., Roth B., Vermathen P., Thoeny H.C.
ISSN
1527-3792 (Electronic)
ISSN-L
0022-5347
Publication state
Published
Issued date
08/2014
Peer-reviewed
Oui
Volume
192
Number
2
Pages
434-439
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Little data are available on noninvasive magnetic resonance imaging based assessment of renal function during upper urinary tract obstruction. We determined whether functional multiparametric kidney magnetic resonance imaging could monitor the treatment response in cases of acute unilateral upper urinary tract obstruction.
Between January 2008 and January 2010, 18 patients with acute unilateral upper urinary tract obstruction due to calculi were prospectively enrolled to undergo kidney magnetic resonance imaging with conventional, blood oxygen level dependent and diffusion-weighted sequences upon emergency hospital admission and after release of obstruction. We assessed functional imaging parameters of obstructed and contralateral unobstructed kidneys derived from blood oxygen level dependent (apparent spin relaxation rate) and diffusion-weighted (total apparent diffusion coefficient, pure diffusion coefficient and perfusion fraction) sequences during acute upper urinary tract obstruction and after its release.
During acute obstruction the apparent spin relaxation rate and perfusion fraction were lower in the cortex (p=0.020 and 0.031) and medulla (p=0.012 and 0.190, respectively) of obstructed kidneys compared to contralateral unobstructed kidneys. After obstruction release the apparent spin relaxation rate and perfusion fraction increased in the cortex (p=0.016 and 0.004) and medulla (p=0.071 and 0.044, respectively) of formerly obstructed kidneys to values similar to those in contralateral kidneys. Total apparent diffusion coefficient and pure diffusion coefficient values did not significantly differ between obstructed and contralateral unobstructed kidneys during or after obstruction.
In our patients with acute unilateral upper urinary tract obstruction due to calculi functional kidney magnetic resonance imaging using blood oxygen level dependent and diffusion-weighted sequences enabled us to monitor pathophysiological changes in obstructed kidneys during obstruction and after its release.
Keywords
Adult, Aged, Diffusion Magnetic Resonance Imaging, Female, Humans, Kidney/physiopathology, Male, Middle Aged, Oxygen/blood, Prospective Studies, Ureteral Obstruction/etiology, Ureteral Obstruction/physiopathology, Ureteral Obstruction/therapy, Urinary Calculi/complications, Urinary Calculi/physiopathology, diffusion magnetic resonance imaging, kidney, magnetic resonance imaging, ureteral obstruction, urinary calculi
Pubmed
Web of science
Create date
08/01/2021 15:35
Last modification date
09/01/2021 6:26
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