2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0.

Details

Serval ID
serval:BIB_0A40744EDF84
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0.
Journal
HIV medicine
Author(s)
Ryom L., Cotter A., De Miguel R., Béguelin C., Podlekareva D., Arribas J.R., Marzolini C., Mallon P., Rauch A., Kirk O., Molina J.M., Guaraldi G., Winston A., Bhagani S., Cinque P., Kowalska J.D., Collins S., Battegay M.
Working group(s)
EACS Governing Board
Contributor(s)
De Miguel Buckley R., d'Arminio Monforte A., Bracchi M., Dedes N., Horban A., Katlama C., Latysheva I., Lundgren J.D., McCormack S., Mussini C., Pozniak A., Pulido F., Raffi F., Reiss P., Stellbrink H.J., Vasylyev M., Gibbons S., Livio F., Behrens G., Bower M., Compston J., De Wit S., Fabbri L.M., Fux C.A., Gisslen M., Lundgren J.D., Martínez E., Miro J.M., Negredo E., Poulter N., Reiss P., Sebastiani G., Berenguer J., Boesecke C., Bruno R., Konov S., Lacombe K., Mauss S., Mendão L., Peters L., Puoti M., Rockstroh J.K., Ambrosioni J., De Castro N., Fätkenheuer G., Furrer H., Miro J.M., Oprea C., Pozniak A., Volny-Anne A., Rockstroh J.K., Sullivan A., Martínez E., Mulcahy F., d'Arminio Monforte A., Behrens G., Katlama C., Lundgren J.D., Mussini C., Oprea C., Pozniak A., Reiss P., Wensing A.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Publication state
Published
Issued date
11/2020
Peer-reviewed
Oui
Volume
21
Number
10
Pages
617-624
Language
english
Notes
Publication types: Journal Article ; Practice Guideline
Publication Status: ppublish
Abstract
The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years.
The 2019 Guidelines were extended with a new section focusing on drug-drug interactions and other prescribing issues in people living with HIV (PLWH). The recommendations for treatment-naïve PLWH were updated with four preferred regimens favouring unboosted integrase inhibitors. A two-drug regimen with dolutegravir and lamivudine, and a three-drug regimen including doravirine were also added to the recommended initial regimens. Lower thresholds for hypertension were expanded to all PLWH and for cardiovascular disease prevention, the 10-year predicted risk threshold for consideration of antiretroviral therapy (ART) modification was lowered from 20% to 10%. Frailty and obesity were added as new topics. It was specified to use urine albumin to creatinine ratio to screen for glomerular disease and urine protein to creatinine ratio for tubular diseases, and thresholds were streamlined with the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations. Hepatitis C virus (HCV) treatment recommendations were split into preferred and alternative treatment options. The algorithm for management of recently acquired HCV infection was updated and includes recommendations for early chronic infection management. Treatment of resistant tuberculosis (TB) was streamlined with the World Health Organization (WHO) recommendations, and new tables on immune reconstitution inflammatory syndrome, on when to start ART in the presence of opportunistic infections and on TB drug dosing were included.
The EACS Guidelines underwent major revisions of all sections in 2019. They are available in four different formats including a new interactive web-based version and are translated into Chinese, French, German, Japanese, Portuguese, Russian and Spanish.
Keywords
Age Factors, Anti-Retroviral Agents/therapeutic use, Comorbidity, Drug Interactions, Drug Therapy, Combination, HIV Infections/drug therapy, HIV Integrase Inhibitors/therapeutic use, Heterocyclic Compounds, 3-Ring/therapeutic use, Humans, Lamivudine/therapeutic use, Oxazines/therapeutic use, Piperazines/therapeutic use, Pyridones/therapeutic use, Treatment Outcome, Triazoles/therapeutic use, European AIDS Clinical Society (EACS) Guidelines, HIV, antiretroviral treatment, comorbidities, drug-drug interactions, hepatitis B virus, hepatitis C virus, opportunistic infections, prescribing in elderly patients
Pubmed
Web of science
Open Access
Yes
Create date
23/09/2022 13:25
Last modification date
27/09/2022 5:40
Usage data