Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.

Details

Serval ID
serval:BIB_0A402E4521F1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers.
Journal
Journal of Virology
Author(s)
Vigneault F., Woods M., Buzon M.J., Li C., Pereyra F., Crosby S.D., Rychert J., Church G., Martinez-Picado J., Rosenberg E.S., Telenti A., Yu X.G., Lichterfeld M.
ISSN
1098-5514 (Electronic)
ISSN-L
0022-538X
Publication state
Published
Issued date
2011
Volume
85
Number
6
Pages
3015-3019
Language
english
Abstract
Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral replication in the absence of antiretroviral therapy (ART), but their underlying immunological and virological characteristics may vary. Here, we used a whole-genome transcriptional profiling approach to characterize gene expression signatures of CD4 T cells from an unselected cohort of elite controllers. The transcriptional profiles for the majority of elite controllers were similar to those of ART-treated patients but different from those of HIV-1-negative persons. Yet, a smaller proportion of elite controllers showed an alternative gene expression pattern that was indistinguishable from that of HIV-1-negative persons but different from that of highly active antiretroviral therapy (HAART)-treated individuals. Elite controllers with the latter gene expression signature had significantly higher CD4 T cell counts and lower levels of HIV-1-specific CD8(+) T cell responses but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1 viral loads determined by ultrasensitive single-copy PCR assays, or chemokine receptor polymorphisms. Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons.
Pubmed
Web of science
Open Access
Yes
Create date
07/04/2011 8:47
Last modification date
20/08/2019 12:32
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