R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers

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Serval ID
serval:BIB_0A09E75EECE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers
Journal
American Journal of Hypertension
Author(s)
Zusman R. M., Hui K. Y., Nussberger J., Christensen D. M., Higgins J., Carlson W. D., Schoenfeld D., Haber E.
ISSN
0895-7061 (Print)
Publication state
Published
Issued date
04/1994
Volume
7
Number
4 Pt 1
Pages
295-301
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 micrograms/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 +/- 4/83 +/- 4 to 119 +/- 3/71 +/- 3 mm Hg (mean +/- SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a short-lived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system.
Keywords
Adult Aldosterone/blood Angiotensin II/*blood Blood Pressure/*drug effects Female Homeostasis Humans Male Middle Aged Oligopeptides/adverse effects/*pharmacology Osmolar Concentration Reference Values Renin/*antagonists & inhibitors Urine/chemistry
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2008 17:41
Last modification date
01/10/2019 7:16
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