Maintenance mechanisms of circuit-integrated axons.

Details

Serval ID
serval:BIB_0A03412C79E3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Maintenance mechanisms of circuit-integrated axons.
Journal
Current opinion in neurobiology
Author(s)
Mariano V., Domínguez-Iturza N., Neukomm L.J., Bagni C.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
53
Pages
162-173
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Adult, circuit-integrated neurons must be maintained and supported for the life span of their host. The attenuation of either maintenance or plasticity leads to impaired circuit function and ultimately to neurodegenerative disorders. Over the last few years, significant discoveries of molecular mechanisms were made that mediate the formation and maintenance of axons. Here, we highlight intrinsic and extrinsic mechanisms that ensure the health and survival of axons. We also briefly discuss examples of mutations associated with impaired axonal maintenance identified in specific neurological conditions. A better understanding of these mechanisms will therefore help to define targets for therapeutic interventions.
Keywords
Animals, Axons/metabolism, Biological Transport/physiology, Humans, Mitochondria/metabolism, Neurodegenerative Diseases/metabolism, Neurodevelopmental Disorders/metabolism, Neuroglia/metabolism
Pubmed
Web of science
Create date
17/10/2018 13:22
Last modification date
20/08/2019 13:32
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