Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Details
Serval ID
serval:BIB_09DEA3ACEF50
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Journal
Journal of virology
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
05/2007
Peer-reviewed
Oui
Volume
81
Number
9
Pages
4904-4908
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
Keywords
Antigens, Viral/immunology, Epitopes/genetics, Herpesvirus 4, Human/immunology, Herpesvirus 8, Human/immunology, Humans, Immunity, Cellular/immunology, Immunologic Memory/immunology, Immunophenotyping, T-Lymphocytes/immunology, T-Lymphocytes/virology, Viral Proteins/genetics
Pubmed
Web of science
Publisher's website
Create date
09/05/2023 13:00
Last modification date
29/11/2024 16:51
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