Early nasal continuous positive airway pressure treatment reduces the need for intubation in very low birth weight infants

Details

Serval ID
serval:BIB_09ADB8FB7D66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early nasal continuous positive airway pressure treatment reduces the need for intubation in very low birth weight infants
Journal
European Journal of Pediatrics
Author(s)
Gittermann  M. K., Fusch  C., Gittermann  A. R., Regazzoni  B. M., Moessinger  A. C.
ISSN
0340-6199 (Print)
Publication state
Published
Issued date
05/1997
Volume
156
Number
5
Pages
384-8
Notes
Clinical Trial
Journal Article --- Old month value: May
Abstract
Nasal continuous positive airway pressure (CPAP) applied shortly after birth is said to be an effective treatment of respiratory distress in very low birth weight infants (VLBW). We tested the hypothesis that the use of early nasal CPAP (applied as soon as signs of respiratory distress occurred, usually within 15 min after birth) reduces the need for intubation, the duration of intermittent mandatory ventilation and the incidence of bronchopulmonary dysplasia. All liveborn VLBW infants (birth weight < 1500 g) admitted to our tertiary neonatal intensive care unit in 1990 (historical controls) and in 1993 (early nasal CPAP group) entered the study. The intubation rate was significantly lower after introduction of nasal CPAP (30% vs 53%, P = 0.016). Median duration of intubation was 4.5 days (interquartile range 3-7 days) before versus 6.0 days (2.8-9 days) after nasal CPAP was introduced (P = 0.73). The incidence of bronchopulmonary dysplasia was not reduced significantly (32% vs 30%, P = 0.94). Survival until discharge was 89.5%, before versus 92.9% after introduction of nasal CPAP (P = 0.54). CONCLUSION: Early nasal CPAP is an effective treatment of respiratory distress in VLBW infants, significantly reducing the need for intubation and intermittent mandatory ventilation, without worsening other standard measures of neonatal outcome. We found no significant decrease in the incidence of bronchopulmonary dysplasia.
Keywords
Analysis of Variance Bronchopulmonary Dysplasia/epidemiology/etiology Chi-Square Distribution Female Humans Infant, Newborn Infant, Very Low Birth Weight/*physiology Intensive Care, Neonatal/*methods/standards Intervention Studies Intubation, Intratracheal Logistic Models Male Positive-Pressure Respiration/*methods/standards Respiration, Artificial/methods/standards Respiratory Distress Syndrome, Newborn/*therapy Retrospective Studies Switzerland/epidemiology Treatment Outcome
Pubmed
Web of science
Create date
25/01/2008 13:16
Last modification date
20/08/2019 12:31
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