Expression of CD164 on Malignant T cells in Sézary Syndrome.

Details

Serval ID
serval:BIB_097B800A362F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Expression of CD164 on Malignant T cells in Sézary Syndrome.
Journal
Acta dermato-venereologica
Author(s)
Guenova E., Ignatova D., Chang Y.T., Contassot E., Mehra T., Saulite I., Navarini A.A., Mitev V., Dummer R., Kazakov D.V., French L.E., Hoetzenecker W., Cozzio A.
ISSN
1651-2057 (Electronic)
ISSN-L
0001-5555
Publication state
Published
Issued date
05/2016
Peer-reviewed
Oui
Volume
96
Number
4
Pages
464-467
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Sézary syndrome is a primary cutaneous T-cell lymphoma characterized by pruritic erythroderma, peripheral lymphadenopathy and the presence of malignant T cells in the blood. Unequivocal detection of malignant cells in patients with Sézary syndrome is of important diagnostic, prognostic and therapeutic value. However, no single Sézary syndrome specific cell surface marker has been identified. In a cohort of patients with Sézary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls. CD164 expression was in most cases limited to CD4+CD26- malignant T lymphocytes, unequivocally identified using flow-cytometry by the expression of a specific Vβ clone for each patient. Increased expression of CD164 may be a promising diagnostic parameter and a potential target for a CD164-linked therapeutic approach in Sézary syndrome.
Keywords
Aged, Aged, 80 and over, Biomarkers, Tumor/blood, CD4-Positive T-Lymphocytes/immunology, Case-Control Studies, Cells, Cultured, Dipeptidyl Peptidase 4/blood, Endolyn/blood, Female, Flow Cytometry, Humans, Immunophenotyping/methods, Male, Middle Aged, Phenotype, Sezary Syndrome/blood, Sezary Syndrome/diagnosis, Sezary Syndrome/immunology, Sezary Syndrome/therapy, Skin Neoplasms/blood, Skin Neoplasms/diagnosis, Skin Neoplasms/immunology, Skin Neoplasms/therapy, Treatment Outcome
Pubmed
Web of science
Open Access
Yes
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
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