Effects of growth hormone administration in addition to gonadotrophins in normally ovulating women and polycystic ovary syndrome (PCO) patients.

Details

Serval ID
serval:BIB_097270F98B9F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effects of growth hormone administration in addition to gonadotrophins in normally ovulating women and polycystic ovary syndrome (PCO) patients.
Journal
Human Reproduction
Author(s)
Volpe A., Artini P.G., Barreca A., Minuto F., Coukos G., Genazzani A.R.
ISSN
0268-1161 (Print)
ISSN-L
0268-1161
Publication state
Published
Issued date
1992
Volume
7
Number
10
Pages
1347-1352
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Follicular fluid sex-steroids, insulin-like growth factor-I (IGF-I), IGF-I binding protein (IGF-I-BP) and epidermal growth factor were investigated in patients with polycystic ovaries and normally ovulating women, following ovulation induction with gonadotrophins or growth hormone plus gonadotrophins. Growth hormone supplementation enhanced the ovarian response to gonadotrophins, and significantly increased follicular fluid IGF-I in both groups, without affecting follicular fluid epidermal growth factor; growth hormone supplementation significantly decreased follicular fluid androstenedione in both groups.
Keywords
Adult, Androstenedione/biosynthesis, Carrier Proteins/biosynthesis, Drug Synergism, Epidermal Growth Factor/biosynthesis, Estradiol/biosynthesis, Female, Follicular Fluid/chemistry, Follicular Fluid/drug effects, Gonadotropins/pharmacology, Growth Hormone/pharmacology, Humans, Infertility, Female/drug therapy, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor I/biosynthesis, Ovulation/drug effects, Ovulation Induction/methods, Polycystic Ovary Syndrome/drug therapy, Progesterone/biosynthesis
Pubmed
Web of science
Create date
14/10/2014 12:43
Last modification date
20/08/2019 13:31
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