Cooperative and Competitive Spreading Dynamics on the Human Connectome.

Details

Serval ID
serval:BIB_08F63CD1C4BA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cooperative and Competitive Spreading Dynamics on the Human Connectome.
Journal
Neuron
Author(s)
Mišić B., Betzel R.F., Nematzadeh A., Goñi J., Griffa A., Hagmann P., Flammini A., Ahn Y.Y., Sporns O.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
06/2015
Peer-reviewed
Oui
Volume
86
Number
6
Pages
1518-1529
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
Increasingly detailed data on the network topology of neural circuits create a need for theoretical principles that explain how these networks shape neural communication. Here we use a model of cascade spreading to reveal architectural features of human brain networks that facilitate spreading. Using an anatomical brain network derived from high-resolution diffusion spectrum imaging (DSI), we investigate scenarios where perturbations initiated at seed nodes result in global cascades that interact either cooperatively or competitively. We find that hub regions and a backbone of pathways facilitate early spreading, while the shortest path structure of the connectome enables cooperative effects, accelerating the spread of cascades. Finally, competing cascades become integrated by converging on polysensory associative areas. These findings show that the organizational principles of brain networks shape global communication and facilitate integrative function.
Keywords
Adult, Brain/anatomy & histology, Brain/blood supply, Competitive Behavior, Connectome, Cooperative Behavior, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Nonlinear Dynamics, Oxygen/blood, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
22/07/2015 13:43
Last modification date
20/08/2019 12:31
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