Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.

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State: Public
Version: author
Serval ID
serval:BIB_08D1F4AE3116
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.
Journal
American Journal of Epidemiology
Author(s)
Lubin Jay H., Gaudet Mia M., Olshan Andrew F., Kelsey Karl, Boffetta Paolo, Brennan Paul, Castellsague Xavier, Chen Chu, Curado Maria Paula, Dal Maso Luigino, Daudt Alexander W., Fabianova Eleonora, Fernandez Leticia, Wünsch-Filho Victor, Franceschi Silvia, Herrero Rolando, Koifman Sergio, La Vecchia Carlo, Lazarus Philip, Levi Fabio, Lissowska Jolanta, Mates Ioan Nicolae, Matos Elena, McClean Michael, Menezes Ana, Morgenstern Hal, Muscat Joshua, Eluf-Neto Jose, Purdue Mark P., Rudnai Peter, Schwartz Stephen M., Shangina Oxana, Sturgis Erich M., Szeszenia-Dabrowska Neonilia, Talamini Renato, Wei Qingyi, Winn Deborah, Zhang Zuo-Feng, Hashibe Mia, Hayes Richard B.
ISSN
1476-6256[electronic], 0002-9262[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
171
Number
12
Pages
1250-1261
Language
english
Abstract
Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.
Keywords
Alcohol Drinking/adverse effects, Body Mass Index, Case-Control Studies, Humans, Laryngeal Neoplasms/etiology, Mouth Neoplasms/etiology, Odds Ratio, Pharyngeal Neoplasms/etiology, Risk Factors, Smoking/adverse effects
Pubmed
Web of science
Open Access
Yes
Create date
29/11/2010 17:08
Last modification date
18/10/2019 7:08
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