Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure
Details
Serval ID
serval:BIB_08C8FDC805F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure
Journal
European Journal of Pharmacology
ISSN
0014-2999 (Print)
Publication state
Published
Issued date
09/1985
Volume
115
Number
2-3
Pages
267-76
Notes
Journal Article --- Old month value: Sep 24
Abstract
The hemodynamic and renal electrolyte/function effects of a synthetic peptide (ANF) corresponding to the sequence of the 26 amino acids contained in atrial natriuretic factor (ANF) were assessed in closed-chest dogs in which acute left ventricular failure was produced by coronary artery embolization with 50 micron plastic microspheres. Coronary embolization produced a sustained reduction in cardiac contractility (LV dP/dtmax) and cardiac output which averaged 42 and 44%, respectively. Following a 45 min equilibration period after heart failure induction, most of the hemodynamic functions stabilized. At this time, ANF infused intravenously at 100 pmol/kg per min X 30 min (n = 9) did not lower mean arterial pressure although it increased cardiac output (P less than 0.05) by 17% at only one time period. With the exception of a fall in coronary resistance and an increase in myocardial blood flow, a higher dose of ANF (200 pmol/kg per min) did not consistently alter hemodynamic function. Fractional excretion of sodium (FE Na%) increased 3.4-fold with ANF at 100 pmol/kg per min and 1.8-fold with the 200 pmol/kg per min dose. Neither dose of ANF produced significant effects on renal blood flow (RBF) or glomerular filtration rate (GFR). Plasma angiotensin II which was 91 +/- 20 fmol/ml at baseline increased to 175 +/- 25 fmol/ml (P less than 0.05) 45 min after heart failure induction. However, neither dose of ANF significantly reduced these high circulating angiotensin II levels. These results demonstrate that an infusion of a synthetic ANF stimulated saluresis without altering RBF or GFR, and improved cardiac output in dogs with acute left ventricular failure.
Keywords
Angiotensin II/blood
Animals
Atrial Natriuretic Factor/*pharmacology
Coronary Disease/physiopathology
Creatinine/blood
Dogs
Electrolytes/urine
Female
Heart Failure, Congestive/*physiopathology
Hemodynamic Processes/*drug effects
Kidney Function Tests
Renal Circulation/drug effects
Time Factors
p-Aminohippuric Acid/blood
Pubmed
Web of science
Create date
05/03/2008 17:39
Last modification date
20/08/2019 13:31