Age, smoking and overweight contribute to the development of intestinal metaplasia of the cardia.

Details

Serval ID
serval:BIB_0830FC8F048F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Age, smoking and overweight contribute to the development of intestinal metaplasia of the cardia.
Journal
World Journal of Gastroenterology : Wjg
Author(s)
Felley C., Bouzourene H., VanMelle M.B., Hadengue A., Michetti P., Dorta G., Spahr L., Giostra E., Frossard J.L.
ISSN
1007-9327 (Print)
ISSN-L
1007-9327
Publication state
Published
Issued date
05/2012
Peer-reviewed
Oui
Volume
18
Number
17
Pages
2076-2083
Language
english
Abstract
AIM: To assess the role of Helicobacter pylori (H. pylori), gastroesophageal reflux disease (GERD), age, smoking and body weight on the development of intestinal metaplasia of the gastric cardia (IMC).¦METHODS: Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this study. Endoscopic biopsies from the esophagus, gastroesophageal junction and stomach were evaluated for inflammation, the presence of H. pylori and intestinal metaplasia. The correlation of these factors with the presence of IMC was assessed using logistic regression.¦RESULTS: IMC was observed in 42% of the patients. Patient age, smoking habit and body mass index (BMI) were found as potential contributors to IMC. The risk of developing IMC can be predicted in theory by combining these factors according to the following formula: Risk of IMC = a + s - 2B where a = 2,...6 decade of age, s = 0 for non-smokers or ex-smokers, 1 for < 10 cigarettes/d, 2 for > 10 cigarettes/d and B = 0 for BMI < 25 kg/m² (BMI < 27 kg/m² in females), 1 for BMI > 25 kg/m² (BMI > 27 kg/m² in females). Among potential factors associated with IMC, H. pylori had borderline significance (P = 0.07), while GERD showed no significance.¦CONCLUSION: Age, smoking and BMI are potential factors associated with IMC, while H. pylori and GERD show no significant association. IMC can be predicted in theory by logistic regression analysis.
Keywords
Endoscopy, Gastroesophageal reflux disease, Metaplasia, Helicobacter pylori, Obesity, Smoking
Pubmed
Web of science
Open Access
Yes
Create date
19/06/2012 14:36
Last modification date
20/08/2019 13:30
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