Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
Details
Serval ID
serval:BIB_0800D3949983
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
Journal
Antiviral Research
ISSN
0166-3542 (Print)
Publication state
Published
Issued date
10/2003
Volume
60
Number
2
Pages
103-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Abstract
Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specific membrane alteration, designated membranous web, was recently identified as the site of viral RNA synthesis and, therefore, represents the HCV replication complex. These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C.
Keywords
Amino Acid Sequence
Cell Line
Endoplasmic Reticulum/virology
Hepacivirus/*physiology/ultrastructure
Humans
Intracellular Membranes/metabolism/*virology
Membrane Proteins/*metabolism
Protein Structure, Secondary
RNA, Viral/metabolism
Viral Nonstructural Proteins/*metabolism
Virus Replication/*physiology
Pubmed
Web of science
Create date
25/01/2008 17:06
Last modification date
20/08/2019 13:30