Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex

Details

Serval ID
serval:BIB_0800D3949983
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
Journal
Antiviral Research
Author(s)
Moradpour  D., Gosert  R., Egger  D., Penin  F., Blum  H. E., Bienz  K.
ISSN
0166-3542 (Print)
Publication state
Published
Issued date
10/2003
Volume
60
Number
2
Pages
103-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Oct
Abstract
Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specific membrane alteration, designated membranous web, was recently identified as the site of viral RNA synthesis and, therefore, represents the HCV replication complex. These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C.
Keywords
Amino Acid Sequence Cell Line Endoplasmic Reticulum/virology Hepacivirus/*physiology/ultrastructure Humans Intracellular Membranes/metabolism/*virology Membrane Proteins/*metabolism Protein Structure, Secondary RNA, Viral/metabolism Viral Nonstructural Proteins/*metabolism Virus Replication/*physiology
Pubmed
Web of science
Create date
25/01/2008 16:06
Last modification date
20/08/2019 12:30
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