Early breast cancer: influence of type of boost (electrons vs iridium-192 implant) on local control and cosmesis after conservative surgery and radiation therapy

Details

Serval ID
serval:BIB_07F1D60F4748
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early breast cancer: influence of type of boost (electrons vs iridium-192 implant) on local control and cosmesis after conservative surgery and radiation therapy
Journal
Radiotherapy and Oncology
Author(s)
Touboul  E., Belkacemi  Y., Lefranc  J. P., Uzan  S., Ozsahin  M., Korbas  D., Buffat  L., Balosso  J., Pene  F., Blondon  J., Schlienger  M., Laugier  A.
ISSN
0167-8140
Publication state
Published
Issued date
02/1995
Peer-reviewed
Oui
Volume
34
Number
2
Pages
105-13
Notes
Comparative Study Journal Article --- Old month value: Feb
Abstract
Between December 1981 and December 1988, 329 consecutive patients with stage I and II breast cancers who underwent wide excision (n = 261) or quadrantectomy (n = 68) with (n = 303) or without (n = 26) axillary dissection were referred to radiotherapy. Final margins of resection were microscopically free from tumor involvement in all cases. Radiotherapy consisted in 40-45 Gy over 4-4.5 weeks to the breast, with (n = 168) or without (n = 161) regional nodal irradiation of 45-50 Gy over 4.5-5 weeks. A mean booster dose of 15 Gy was delivered to the primary site by iridium-192 implant in 169 patients (group 1) or by electrons in 160 patients (group 2). Twenty-seven percent (n = 88) of patients received tamoxifen for > or = 2 years. Adjuvant chemotherapy was administered in 22% (n = 71) of patients. Groups 1 and 2 were not strictly comparable. Group 1 patients were significantly younger, had smaller tumors, were treated with cobalt at 5 x 2 Gy per week and axillary dissection was more frequently performed. Group 2 patients were more frequently bifocal and more frequently treated by quadrantectomy and tamoxifen, and irradiation used accelerator photons at 4 x 2.50 Gy per week. No difference in terms of follow-up and survival rates was observed between the two groups. For all patients the 5- and 10-year local breast relapse rates were 6.7% and 11%, respectively. No difference was observed regarding local control either by the electron or the iridium-192 implant boosts. Axillary dissection and age had an impact on the breast cosmetic outcome.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult Age Factors Antineoplastic Combined Chemotherapy Protocols/administration & dosage/therapeutic use *Brachytherapy Breast Neoplasms/*radiotherapy/*surgery Chemotherapy, Adjuvant Cobalt Radioisotopes/administration & dosage/therapeutic use *Esthetics Female Follow-Up Studies Humans Iridium Radioisotopes/administration & dosage/*therapeutic use Lymph Node Excision Mastectomy Mastectomy, Segmental Middle Aged Neoplasm Recurrence, Local/*prevention & control Radiotherapy Dosage *Radiotherapy, High-Energy Survival Rate Tamoxifen/administration & dosage/therapeutic use Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 17:16
Last modification date
20/08/2019 12:30
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