Secondary amyloidosis: a severe complication of ankylosing spondylitis. Two case-reports.

Details

Serval ID
serval:BIB_07EDB0EE5D7B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Secondary amyloidosis: a severe complication of ankylosing spondylitis. Two case-reports.
Journal
Joint, bone, spine : revue du rhumatisme
Author(s)
Kovacsovics-Bankowski M., Zufferey P., So A.K., Gerster J.C.
ISSN
1297-319X
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
67
Number
2
Pages
129-33
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
STUDY OBJECTIVE: To report two cases of amyloidosis secondary to ankylosing spondylitis. PATIENTS AND RESULTS: Of the 47 ankylosing spondylitis patients who have received follow-up at our department over the last few years, two have developed AA amyloidosis. Both have extremely severe, long-standing joint disease, with virtually complete spinal ankylosis and destructive peripheral arthritis of the hips and wrists; one also has tarsal joint destruction. Renal dysfunction was the first manifestation of amyloidosis in both cases. One patient required chronic hemodialysis and developed peritonitis due to colonic perforation, probably at a site of amyloid deposition. CONCLUSIONS: Secondary amyloidosis is a rare complication of ankylosing spondylitis that can cause severe renal and gastrointestinal complications. No treatment capable of clearing established amyloid deposits is available to date.
Keywords
Adult, Amyloidosis, Humans, Male, Middle Aged, Spondylitis, Ankylosing
Pubmed
Web of science
Create date
25/01/2008 8:39
Last modification date
20/08/2019 12:30
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