Vinorelbine with or without Trastuzumab in Metastatic Breast Cancer: A Retrospective Single Institution Series

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State: Public
Version: Final published version
Serval ID
serval:BIB_079DAD2E48CF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vinorelbine with or without Trastuzumab in Metastatic Breast Cancer: A Retrospective Single Institution Series
Journal
Isrn Oncology
Author(s)
Stravodimou A., Zaman K., Voutsadakis I.A.
ISSN
2090-5661 (Print)
2090-567X (Electronic)
ISSN-L
2090-5661
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
2014
Pages
289836
Language
english
Notes
Publication types: Clinical Study ; other Identifiant PubMed Central: PMC4079952
Abstract
Background. We report our experience with vinorelbine, a widely used chemotherapeutic, in unselected metastatic breast cancer patients treated in clinical routine. Patients and Methods. The data of all patients with metastatic breast cancer receiving vinorelbine with or without trastuzumab during a six year period were reviewed. Patients received vinorelbine intravenous 25-30 mg/m(2) or 60-80 mg/m(2) orally in days 1 and 8 of a 21 day cycle. Results. Eighty-seven women were included. Sixty-two patients received vinorelbine alone and 25 patients received vinorelbine in combination with trastuzumab. In 67 patients this was the first line treatment for metastatic disease and in 20 patients it was 2nd or later line of treatment. The median TTP was six months (range: 1-45). The median overall survival was 11.5 months (range: 1-83). Seventy patients were evaluable for response. In patients receiving first line treatment 44.4% had a response while in the second and subsequent lines setting 12.5% of patients responded (P = 0.001). Objective response was obtained in 63.6% of patients receiving concomitant trastuzumab and in 25% of patients receiving vinorelbine alone (P = 0.0002). Conclusion. This study confirms a high disease control rate. Response rate and TTP were superior in first line treatment compared to subsequent lines.
Pubmed
Open Access
Yes
Create date
11/07/2016 11:04
Last modification date
20/08/2019 13:29
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