Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion.

Details

Serval ID
serval:BIB_0795ED63E452
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion.
Journal
Cell metabolism
Author(s)
Geller S., Arribat Y., Netzahualcoyotzi C., Lagarrigue S., Carneiro L., Zhang L., Amati F., Lopez-Mejia I.C., Pellerin L.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Publication state
Published
Issued date
01/10/2019
Peer-reviewed
Oui
Volume
30
Number
4
Pages
833-844.e7
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The hypothalamus plays a key role in the detection of energy substrates to regulate energy homeostasis. Tanycytes, the hypothalamic ependymo-glia, are located at a privileged position to integrate multiple peripheral inputs. We observed that tanycytes produce and secrete Fgf21 and are located close to Fgf21-sensitive neurons. Fasting, likely via the increase in circulating fatty acids, regulates this central Fgf21 production. Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure. Tanycytic Fgf21 deletion triggers an increase in lipolysis, likely due to impaired inhibition of key neurons during fasting. Mice deleted for tanycytic Fgf21 exhibit increased energy expenditure and a reduction in fat mass gain, reminiscent of a browning phenotype. Our results suggest that tanycytes sense free fatty acids to maintain body lipid homeostasis through Fgf21 signaling within the hypothalamus.
Keywords
Fgf21, browning, glial, hypothalamus, liver, monocarboxylates, oleate, palmitate, tanycyte, white adipose tissue
Pubmed
Web of science
Funding(s)
Swiss National Science Foundation / Projects / 320030_170062
Create date
13/09/2019 18:52
Last modification date
21/04/2020 6:19
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