High prevalence of peribronchial focal lesions of airway invasive aspergillosis in hematological cancer patients with prolonged neutropenia.

Details

Serval ID
serval:BIB_0779912D40B1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High prevalence of peribronchial focal lesions of airway invasive aspergillosis in hematological cancer patients with prolonged neutropenia.
Journal
The British journal of radiology
Author(s)
Casutt A., Couchepin J., Brunel A.S., Lovis A., Bochud P.Y., Keller N., Lamoth F., Beigelman-Aubry C.
ISSN
1748-880X (Electronic)
ISSN-L
0007-1285
Publication state
Published
Issued date
01/09/2020
Peer-reviewed
Oui
Volume
93
Number
1113
Pages
20190693
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The aim of this study is to characterize chest CT findings of neutropenic patients with proven/probable invasive pulmonary aspergillosis (IPA).
Hematological cancer patients admitted to our institution (2007-2017) were retrospectively enrolled if the diagnostic criteria of proven/probable IPA during the neutropenia were met (EORTC/MSG). Galactomannan (GM) was routinely measured in serum and chest CT-scan was routinely performed in case of recurrent/persistent fever. Bronchoscopy was performed in case of chest CT-scan abnormalities. Chest CT-scan and GM dosage were analyzed at the time of IPA suspicion. Chest lesions were classified using a clinical report form by two expert radiologists.
35 patients were identified. Peribronchial focal lesions were observed in 29 IPA (82.9%) by the first radiologist and in 31 (88.5%) by the second (k = 0.768). 12 weeks mortality was 20%.
Peribronchial focal lesions are a common finding in early-IPA whatever the GM value during neutropenia and our findings reinforce the efficiency of a preemptive approach.
Peribronchial focal lesions, which are classically described in airway invasive aspergillosis, are a common finding in early-IPA in hematological cancer patients with prolonged neutropenia regardless of the GM value, and such peribronchial lesions should reinforce the possibility of IPA.
Keywords
Adult, Aged, Biomarkers/blood, Bronchial Diseases/diagnostic imaging, Bronchoscopy, Female, Hematologic Neoplasms/blood, Hematologic Neoplasms/complications, Humans, Invasive Pulmonary Aspergillosis/blood, Invasive Pulmonary Aspergillosis/diagnostic imaging, Male, Mannans/blood, Middle Aged, Neutropenia/blood, Neutropenia/chemically induced, Neutropenia/complications, Prevalence, Retrospective Studies, Tomography, X-Ray Computed, Young Adult
Pubmed
Web of science
Create date
10/06/2020 20:44
Last modification date
27/02/2021 15:43
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