Transient inhibition of angiotensinogen production in transgenic mice bearing an antisense angiotensinogen gene.

Details

Serval ID
serval:BIB_0765AFF9B27A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transient inhibition of angiotensinogen production in transgenic mice bearing an antisense angiotensinogen gene.
Journal
Kidney International
Author(s)
Pedrazzini T., Cousin P., Aubert J.F., Brunner H.R.
ISSN
0085-2538
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
47
Number
6
Pages
1638-1346
Language
english
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
Angiotensinogen is the precursor of the biologically active hormone angiotensin II. Enzyme kinetic parameters suggest that concentrations of plasma angiotensinogen are rate limiting in the renin reaction. It is therefore assumed that a decrease in angiotensinogen synthesis in vivo would result in a decrease in angiotensin II plasma levels and then of blood pressure. To test this hypothesis, we generated a transgenic mouse line that carries an inducible antisense angiotensinogen gene. Transient inhibition of angiotensinogen synthesis could be demonstrated in these transgenic animals. However, the amounts of liver angiotensinogen message and plasma angiotensinogen concentrations were rapidly back to levels observed in control animals.
Keywords
Angiotensinogen, Animals, Animals, Newborn, Antisense Elements (Genetics), Base Sequence, Blood Pressure, Dietary Proteins, Gene Expression, Genes, Heart Rate, Male, Mice, Mice, Inbred Strains, Mice, Transgenic, Molecular Sequence Data, Oligonucleotide Probes, RNA, Messenger, Rats, Reference Values
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:45
Last modification date
08/05/2019 14:01
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