Towards an optimal reference region in single-photon emission tomography difference images in epilepsy

Details

Serval ID
serval:BIB_0754EFDC150D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Towards an optimal reference region in single-photon emission tomography difference images in epilepsy
Journal
Eur J Nucl Med
Author(s)
Boussion N., Ryvlin P., Isnard J., Houzard C., Mauguiere F., Cinotti L.
ISSN
0340-6997 (Print)
ISSN-L
0340-6997
Publication state
Published
Issued date
02/2000
Volume
27
Number
2
Pages
155-60
Language
english
Notes
Boussion, N
Ryvlin, P
Isnard, J
Houzard, C
Mauguiere, F
Cinotti, L
eng
Germany
Eur J Nucl Med. 2000 Feb;27(2):155-60.
Abstract
There is marked variability in the cerebral blood flow (CBF) between the ictal and interictal state in epilepsy, and it would therefore be desirable to increase the reliability of ictal/interictal single-photon emission tomography (SPET) difference images. We aimed to improve the step of quantitative normalization of images by finding the best possible reference region. In 16 patients (11 with lateralization of the epileptogenic focus, five with bilateral foci) both ictal and inter-ictal SPET scans were performed after injection of technetium-99m labelled tracer. Then, each region among a selected set (brain+cerebellum, brain, cerebellum, hemispheres, and for patients with an expected lateralization, cortical lobe containing the focus and symmetrical contralateral lobe) was investigated by comparison of the regional ictal/inter-ictal variance in counts. Among patients with a suspected lateralized focus, the distribution of CBF in the contralateral cortical lobe appeared to vary less between ictal and inter-ictal states than in other investigated areas. As a consequence, this latter region constitutes the best choice as a reference region. For patients with bilateral foci, the cerebellum appears to be a good compromise even though it presents with significant CBF changes.
Keywords
Brain/blood supply/*diagnostic imaging, Case-Control Studies, Cerebrovascular Circulation, Cysteine/analogs & derivatives, Epilepsies, Partial/*diagnostic imaging, Humans, Image Processing, Computer-Assisted, Organotechnetium Compounds, Radiopharmaceuticals, *Tomography, Emission-Computed, Single-Photon
Pubmed
Create date
29/11/2018 13:36
Last modification date
20/08/2019 13:29
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