Antihypertensive effect of diltiazem administered once and twice daily

Details

Serval ID
serval:BIB_075227401565
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antihypertensive effect of diltiazem administered once and twice daily
Journal
Journal of Human Hypertension
Author(s)
Mooser  V., Waeber  B., Nussberger  J., Brunner  H. R.
ISSN
0950-9240 (Print)
Publication state
Published
Issued date
12/1988
Volume
2
Number
4
Pages
257-60
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
This study was undertaken to compare the antihypertensive effect of diltiazem administered once or twice daily. After a two week wash-out period, eight hypertensive patients were treated for two consecutive four week phases with 180 mg once daily or 90 mg twice daily of a sustained-release formulation of diltiazem. The sequence of the treatments was randomised and the trial carried out in a double-blind fashion. Ambulatory daytime BP profiles were obtained using a portable BP recorder (Remler M2000). The average of all BP readings taken during the monitoring period was 159/104 +/- 21/10 mgHg (mean +/- SD) at the end of the wash-out period and 145/90 +/- 20/12 and 148/95 +/- 21/11 mmHg under treatment with diltiazem 180 mg once daily and 90 mg twice daily, respectively. These data indicate that 180 mg of a slow-release formulation of diltiazem are as effective in lowering the BP of hypertensive patients when administered daily in a single dose as when divided into two doses.
Keywords
Adult Aged Antihypertensive Agents/administration & dosage/*pharmacology Blood Pressure/drug effects Diltiazem/administration & dosage/*pharmacology Drug Administration Schedule Female Heart Rate/drug effects Humans Male Middle Aged
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 12:29
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