Circulating CD56<sup>bright</sup> NK cells inversely correlate with survival of melanoma patients.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_07410EEFFC5B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circulating CD56<sup>bright</sup> NK cells inversely correlate with survival of melanoma patients.
Journal
Scientific reports
Author(s)
de Jonge K., Ebering A., Nassiri S., Maby-El Hajjami H., Ouertatani-Sakouhi H., Baumgaertner P., Speiser D.E.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
14/03/2019
Peer-reviewed
Oui
Volume
9
Number
1
Pages
4487
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The roles of NK cells in human melanoma remain only partially understood. We characterized NK cells from peripheral blood ex vivo by flow cytometry obtained from late stage (III/IV) melanoma patients. Interestingly, we found that the abundance of CD56 <sup>bright</sup> NK cells negatively correlate with overall patient survival, together with distant metastases, in a multivariate cox regression analysis. The patients' CD56 <sup>bright</sup> NK cells showed upregulation of CD11a, CD38 and CD95 as compared to healthy controls, pointing to an activated phenotype as well as a possible immune regulatory role in melanoma patients. After stimulation in vitro, CD56 <sup>bright</sup> NK cells produced less TNFα and GMCSF in patients than controls. Furthermore, IFNγ production by the CD56 <sup>bright</sup> NK cells correlated inversely with overall survival. Our results highlight that abundance and function of CD56 <sup>bright</sup> NK cells are associated with melanoma patient survival, emphasizing the potential of NK cell subsets for biomarker discovery and future therapeutic targeting.
Pubmed
Web of science
Open Access
Yes
Create date
07/04/2019 16:15
Last modification date
20/10/2020 6:23
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