Le tissu adipeux: une veritable glande endocrine synthetisant hormones et cytokines: implications cliniques. [Adipose tissue: a real endocrine gland synthesizing hormones and cytokines: clinical implications]

Details

Serval ID
serval:BIB_07328959FCB4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Le tissu adipeux: une veritable glande endocrine synthetisant hormones et cytokines: implications cliniques. [Adipose tissue: a real endocrine gland synthesizing hormones and cytokines: clinical implications]
Journal
Revue Médicale de la Suisse Romande
Author(s)
Martin-Du Pan  R. C., Giusti  V.
ISSN
0035-3655 (Print)
Publication state
Published
Issued date
03/2004
Volume
124
Number
3
Pages
171-5
Notes
English Abstract
Journal Article
Review --- Old month value: Mar
Abstract
Adipose tissue (AT) is not considered anymore as a passive depot for storing excess energy in the form of triglycerides but as an active organ secreting several hormones or adipokines. With the exception of adiponectin the serum levels of adipokines are increased in obesity. Leptin regulates food intake, reproductive and immune system. Adiponectin decreases insulin resistance and has antiinflammatory properties. On the contrary, resisting, tumor necrosis factor and Interleukin-6 are diabetogenic and induce inflammatory reactions. It is believed that atherosclerosis is due to the inflammation induced by oxydized LDL-cholesterol in vessels. Abdominal obesity is associated with increased incidence of metabolic disorders and insulin resistance. The role of adipokines in these disorders is described as well as their role in the antidiabetic effect of thiazo-linedinediones. AT contains also enzymes responsible for the aromatization of androstenedione into estrone, which could explain an increase of breast and uterus cancer in obese people.
Keywords
Adiponectin Adipose Tissue/*metabolism Cytokines/*biosynthesis Fatty Acids/metabolism Hormones/*biosynthesis Humans Insulin Resistance *Intercellular Signaling Peptides and Proteins Interleukin-6/biosynthesis Leptin/biosynthesis Obesity/etiology Protein Biosynthesis Thiazolidinediones/metabolism Tumor Necrosis Factor-alpha/biosynthesis
Pubmed
Create date
25/01/2008 16:23
Last modification date
20/08/2019 12:29
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