A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control study

Details

Serval ID
serval:BIB_0726B416697D
Type
Article: article from journal or magazin.
Collection
Publications
Title
A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control study
Journal
American Journal of Gastroenterology
Author(s)
Sousa Guerreiro C., Cravo M., Costa A.R., Miranda A., Tavares L., Moura-Santos P., MarquesVidal P., Nobre Leitão C.
ISSN
0002-9270 (Print)
ISSN-L
0002-9270
Publication state
Published
Issued date
2006
Volume
102
Number
11
Pages
2551-2556
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OBJECTIVES: Evaluate the nutritional status of patients with inactive or mildly active Crohn's disease (CD), and identify possible causes for potential deficiencies.
METHODS: A total of 78 CD patients and 80 healthy controls were evaluated in respect of nutritional status, dietary intake, and life styles factors.
RESULTS: These 73/78 CD patients were on immunomodulating therapies. Mean body mass index (BMI) was lower in patients as compared to controls (P= 0.006) but 32% of CD patients and 33.8% of controls had a BMI > 25, whereas 8% and 23.8% in each group, respectively, were obese (BMI > 30Kg/m(2)). Fat free mass was significantly decreased in both genders (P < 0.05) whereas fat mass was decreased only in males (P= 0.01). Energy intake was significantly lower in CD patients (P < 0.0001) and we observed significantly lower adjusted mean daily intakes of carbohydrates, monounsaturated fat, fiber, calcium, and vitamins C, D, E, and K (P < 0.05). 29% of patients had excluded grains from their usual diet, 28% milk, 18% vegetables, and 11% fruits. Milk exclusion resulted in a significantly lower consumption of calcium and vitamin K (P < 0.001) and the exclusion of vegetables was associated to a lower consumption of vitamins C and E (P < 0.05). Physical activity was significantly lower in CD patients (P= 0.01) and this lack of physical activity was inversely correlated with increased fat mass percentage (r=-0.315, P= 0.001).
CONCLUSIONS: Results showed that the most prevalent form of malnutrition in CD patients was an excess of body weight, which was concomitant with an inadequate dietary intake, namely micronutrients, clearly related to dietary exclusion of certain foods.
Keywords
Crohn Disease/complications, Crohn Disease/therapy, Nutrition Disorders/epidemiology, Nutrition Disorders/etiology, Portugal/epidemiology
Pubmed
Web of science
Create date
01/12/2016 15:01
Last modification date
22/07/2020 5:26
Usage data