Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells.

Details

Serval ID
serval:BIB_06F683976602
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells.
Journal
Immunological reviews
Author(s)
Wang H., Lu C.H., Ho P.C.
ISSN
1600-065X (Electronic)
ISSN-L
0105-2896
Publication state
Published
Issued date
05/2020
Peer-reviewed
Oui
Volume
295
Number
1
Pages
126-139
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The diverse distribution and functions of regulatory T cells (Tregs) ensure tissue and immune homeostasis; however, it remains unclear which factors can guide distribution, local differentiation, and tissue context-specific behavior in Tregs. Although the emerging concept that Tregs could re-adjust their transcriptome based on their habitations is supported by recent findings, the underlying mechanisms that reprogram transcriptome in Tregs are unknown. In the past decade, metabolic machineries have been revealed as a new regulatory circuit, known as immunometabolic regulation, to orchestrate activation, differentiation, and functions in a variety of immune cells, including Tregs. Given that systemic and local alterations of nutrient availability and metabolite profile associate with perturbation of Treg abundance and functions, it highlights that immunometabolic regulation may be one of the mechanisms that orchestrate tissue context-specific regulation in Tregs. The understanding on how metabolic program instructs Tregs in peripheral tissues not only represents a critical opportunity to delineate a new avenue in Treg biology but also provides a unique window to harness Treg-targeting approaches for treating cancer and autoimmunity with minimizing side effects. This review will highlight the metabolic features on guiding Treg formation and function in a disease-oriented perspective and aim to pave the foundation for future studies.
Keywords
Anesthesiology/legislation & jurisprudence, Child, Germany, West, Humans, Male, Physical Examination, autoimmunity, cancer, immunometabolism, inflammation, metabolic adaptation, regulatory T cell
Pubmed
Web of science
Create date
21/05/2020 12:39
Last modification date
22/05/2020 5:26
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