Failure to Integrate Quantitative Measurement Methods of Ocular Inflammation Hampers Clinical Practice and Trials on New Therapies for Posterior Uveitis.

Details

Serval ID
serval:BIB_06E63B8CAB36
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Failure to Integrate Quantitative Measurement Methods of Ocular Inflammation Hampers Clinical Practice and Trials on New Therapies for Posterior Uveitis.
Journal
Journal of ocular pharmacology and therapeutics
Author(s)
Herbort C.P., Tugal-Tutkun I., Neri P., Pavésio C., Onal S., LeHoang P.
ISSN
1557-7732 (Electronic)
ISSN-L
1080-7683
Publication state
Published
Issued date
05/2017
Peer-reviewed
Oui
Volume
33
Number
4
Pages
263-277
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Uveitis is one of the fields in ophthalmology where a tremendous evolution took place in the past 25 years. Not only did we gain access to more efficient, more targeted, and better tolerated therapies, but also in parallel precise and quantitative measurement methods developed allowing the clinician to evaluate these therapies and adjust therapeutic intervention with a high degree of precision. Objective and quantitative measurement of the global level of intraocular inflammation became possible for most inflammatory diseases with direct or spill-over anterior chamber inflammation, thanks to laser flare photometry. The amount of retinal inflammation could be quantified by using fluorescein angiography to score retinal angiographic signs. Indocyanine green angiography gave imaging insight into the hitherto inaccessible choroidal compartment, rendering possible the quantification of choroiditis by scoring indocyanine green angiographic signs. Optical coherence tomography has enabled measurement and objective monitoring of retinal and choroidal thickness. This multimodal quantitative appraisal of intraocular inflammation represents an exquisite security in monitoring uveitis. What is enigmatic, however, is the slow pace with which these improvements are integrated in some areas. What is even more difficult to understand is the fact that clinical trials to assess new therapeutic agents still mostly rely on subjective parameters such as clinical evaluation of vitreous haze as a main endpoint; whereas a whole array of precise, quantitative, and objective modalities are available for the design of clinical studies. The scope of this work was to review the quantitative investigations that improved the management of uveitis in the past 2-3 decades.

Keywords
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, Eye Infections/drug therapy, Humans, Inflammation/drug therapy, Uveitis, Posterior/drug therapy, fundus fluorescein angiography, indocyanine green angiography, laser flare photometry, optical coherence tomography, outcome measures, uveitis
Pubmed
Web of science
Create date
22/12/2016 11:55
Last modification date
20/08/2019 12:29
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