Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients

Details

Serval ID
serval:BIB_06D42A72E87D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients
Journal
Stroke
Author(s)
Wintermark M., Reichhart M., Cuisenaire O., Maeder P., Thiran J. P., Schnyder P., Bogousslavsky J., Meuli R.
ISSN
1524-4628
Publication state
Published
Issued date
08/2002
Peer-reviewed
Oui
Volume
33
Number
8
Pages
2025-2031
Language
english
Notes
Clinical Trial Comparative Study Wintermark, M Reichhart, M Cuisenaire, O Maeder, P Thiran, J-P Schnyder, P Bogousslavsky, J Meuli, R United States Stroke; a journal of cerebral circulation Stroke. 2002 Aug;33(8):2025-31. --- Old month value: Aug
Abstract
BACKGROUND AND PURPOSE: Besides classic criteria, cerebral perfusion imaging could improve patient selection for thrombolytic therapy. The purpose of this study was to compare quantitative perfusion CT imaging and qualitative diffusion- and perfusion-weighted MRI (DWI and PWI) in acute stroke patients at the time of their emergency evaluation. METHODS: Thirteen acute stroke patients underwent perfusion CT and DWI or PWI on admission. The size of infarct and ischemic lesion (infarct plus penumbra) on the admission perfusion CT was compared with that of the MR abnormalities as shown on the DWI trace and on the relative cerebral blood volume, cerebral blood flow, time to peak, and mean transit time maps calculated from PWI studies. RESULTS: The most significant correlation was found between infarct size on the admission perfusion CT and abnormality size on the admission DWI map (r=0.968, P<0.001). A significant correlation was also observed between the size of the ischemic lesion (infarct plus penumbra) on the admission perfusion CT and the abnormality size on the mean transit time map calculated from admission PWI (r=0.946, P<0.001). Information about cerebral infarct and total ischemia (infarct plus penumbra) carried by both imaging techniques was similar, with slopes of 0.913 and 0.905, respectively. CONCLUSIONS: An imaging technique may be helpful in the identification of cerebral penumbra in acute stroke patients and thus in the selection of patients for thrombolytic therapy. Perfusion CT and DWI/PWI are equivalent in this task.
Keywords
Acute Disease Aged Blood Flow Velocity Blood Volume Cerebral Angiography Cerebral Infarction/complications/diagnosis/therapy Cerebrovascular Circulation Diagnostic Tests, Routine Diffusion Female Humans *Magnetic Resonance Imaging/methods Male Middle Aged Patient Selection Perfusion Predictive Value of Tests Prospective Studies Stroke/complications/*diagnosis/therapy Thrombolytic Therapy Time Factors *Tomography, X-Ray Computed
Pubmed
Web of science
Open Access
Yes
Create date
11/04/2008 8:23
Last modification date
20/08/2019 12:29
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