Gastroschisis in Europe - A Case-malformed-Control Study of Medication and Maternal Illness during Pregnancy as Risk Factors.

Details

Serval ID
serval:BIB_06CE9B795C24
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gastroschisis in Europe - A Case-malformed-Control Study of Medication and Maternal Illness during Pregnancy as Risk Factors.
Journal
Paediatric and perinatal epidemiology
Author(s)
Given J.E., Loane M., Garne E., Nelen V., Barisic I., Randrianaivo H., Khoshnood B., Wiesel A., Rissmann A., Lynch C., Neville A.J., Pierini A., Bakker M., Klungsoyr K., Latos Bielenska A., Cavero-Carbonell C., Addor M.C., Zymak-Zakutnya N., Tucker D., Dolk H.
ISSN
1365-3016 (Electronic)
ISSN-L
0269-5022
Publication state
Published
Issued date
11/2017
Peer-reviewed
Oui
Volume
31
Number
6
Pages
549-559
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Gastroschisis, a congenital anomaly of the abdomen, is associated with young maternal age and has increased in prevalence in many countries. Maternal illness and medication exposure are among environmental risk factors implicated in its aetiology.
A population-based case-malformed control study was conducted using data from 18 European congenital anomaly registries, with information on first trimester medication use, covering 8 million births 1995-2012. 1577 gastroschisis cases (of which 4% stillbirths, 11% terminations of pregnancy) were compared to 153 357 non-chromosomal/monogenic controls. Literature review identified previous associations concerning maternal illness and medication exposure to be tested as signals. Logistic regression adjusted for maternal age group, registry, and time period was used to evaluate associations.
Comparing gastroschisis to other congenital anomalies, the data supported signals concerning maternal depression (aOR 2.52, 95% CI 1.45, 4.39), antidepressant use (aOR 2.03, 95% CI 1.22, 3.38), postnatal depression/psychosis following a previous pregnancy (aOR 8.32, 95% CI 2.56, 27.01), sexually transmitted infections (aOR 2.85, 95% CI 1.13, 7.24), topical antivirals (aOR 5.31, 95% CI 1.63, 17.33), and continuation of oral contraceptives in early pregnancy (aOR 2.17, 95% CI 1.13, 4.18). Exploratory analyses suggested associations with a wider range of maternal infections and medications, including tonsillitis and the expectorant bromhexine.
While it is difficult to disentangle the effects of the medication and underlying indication, our results add to the evidence base on preventable risk factors for gastroschisis. These risk factors may contribute to the higher risk among young mothers, and geographical and temporal variation in prevalence.
Keywords
Adolescent, Antidepressive Agents/therapeutic use, Antiviral Agents/therapeutic use, Case-Control Studies, Contraceptives, Oral/therapeutic use, Europe/epidemiology, Female, Gastroschisis/diagnosis, Gastroschisis/epidemiology, Humans, Maternal Age, Mental Disorders/diagnosis, Mental Disorders/drug therapy, Pregnancy, Pregnancy Trimester, First/drug effects, Prevalence, Risk Factors, Sexually Transmitted Diseases/epidemiology, Sexually Transmitted Diseases/prevention & control, Young Adult, Antidepressive Agents, Antiviral Agents, Congenital Abnormalities, Depression, Gastroschisis, Mental Disorders, Oral Contraceptives, Sexually Transmitted Diseases
Pubmed
Web of science
Create date
01/11/2017 10:46
Last modification date
20/08/2019 12:29
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