Health utility indexes in patients with acute coronary syndromes

Details

Serval ID
serval:BIB_06CE0E333A89
Type
Article: article from journal or magazin.
Collection
Publications
Title
Health utility indexes in patients with acute coronary syndromes
Journal
Open Heart
Author(s)
Gencer B., Rodondi N., Auer R., Nanchen D., Raber L., Klingenberg R., Pletscher M., Juni P., Windecker S., Matter C. M., Luscher T. F., Mach F., Perneger T. V., Girardin F. R.
ISSN
2053-3624 (Print)
ISSN-L
2053-3624
Publication state
Published
Issued date
2016
Volume
3
Number
1
Pages
e000419
Language
english
Notes
Gencer, Baris
Rodondi, Nicolas
Auer, Reto
Nanchen, David
Raber, Lorenz
Klingenberg, Roland
Pletscher, Mark
Juni, Peter
Windecker, Stephan
Matter, Christian M
Luscher, Thomas F
Mach, Francois
Perneger, Thomas V
Girardin, Francois R
eng
Research Support, Non-U.S. Gov't
England
Open Heart. 2016 May 23;3(1):e000419. doi: 10.1136/openhrt-2016-000419. eCollection 2016.
Abstract
BACKGROUND: Acute coronary syndromes (ACS) have been associated with lower health utilities (HUs) compared with the general population. Given the prognostic improvements after ACS with the implementation of coronary angiography (eg, percutaneous coronary intervention (PCI)), contemporary HU values derived from patient-reported outcomes are needed. METHODS: We analysed data of 1882 patients with ACS 1 year after coronary angiography in a Swiss prospective cohort. We used the EuroQol five-dimensional questionnaire (EQ-5D) and visual analogue scale (VAS) to derive HU indexes. We estimated the effects of clinical factors on HU using a linear regression model and compared the observed HU with the average values of individuals of the same sex and age in the general population. RESULTS: Mean EQ-5D HU 1-year after coronary angiography for ACS was 0.82 (+/-0.16) and mean VAS was 0.77 (+/-0.18); 40.9% of participants exhibited the highest utility values. Compared with population controls, the mean EQ-5D HU was similar (expected mean 0.82, p=0.58) in patients with ACS, but the mean VAS was slightly lower (expected mean 0.79, p<0.001). Patients with ACS who are younger than 60 years had lower HU than the general population (<0.001). In patients with ACS, significant differences were found according to the gender, education and employment status, diabetes, obesity, heart failure, recurrent ischaemic or incident bleeding event and participation in cardiac rehabilitation (p<0.01). CONCLUSIONS: At 1 year, patients with ACS with coronary angiography had HU indexes similar to a control population. Subgroup analyses based on patients' characteristics and further disease-specific instruments could provide better sensitivity for detecting smaller variations in health-related quality of life.
Keywords
*Acute coronary syndromes, *health utility, *patient-reported outcomes, *quality of life
Pubmed
Create date
10/02/2021 13:24
Last modification date
11/02/2021 7:26
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