Endometrial effects, bleeding control, and compliance with a new postmenopausal hormone therapy regimen based on transdermal estradiol gel and every-other-day vaginal progesterone in capsules: a 3-year pilot study

Details

Serval ID
serval:BIB_06BD40792066
Type
Article: article from journal or magazin.
Collection
Publications
Title
Endometrial effects, bleeding control, and compliance with a new postmenopausal hormone therapy regimen based on transdermal estradiol gel and every-other-day vaginal progesterone in capsules: a 3-year pilot study
Journal
Fertility and Sterility
Author(s)
Cicinelli  E., de Ziegler  D., Alfonso  R., Nicoletti  R., Bellavia  M., Colafiglio  G.
ISSN
1556-5653
Publication state
Published
Issued date
06/2005
Peer-reviewed
Oui
Volume
83
Number
6
Pages
1859-63
Notes
Journal Article --- Old month value: Jun
Abstract
In a 3-year prospective study, 30 postmenopausal women received transdermal E2 gel and every-other-day vaginal P in capsules. At study completion, endometrial thickness was significantly reduced as compared with baseline (2.7 +/- 0.5 vs. 3.4 +/- 0.9 mm), endometrial biopsy showed endometrial atrophy in all cases, and amenorrhea was achieved in 92.6% of cycles, while excellent patient satisfaction was achieved.
Keywords
Administration, Cutaneous Administration, Intravaginal Capsules Drug Administration Schedule Endometrium/blood supply/*drug effects/pathology Estradiol/*administration & dosage Estrogen Replacement Therapy/*methods Female Humans Middle Aged Patient Compliance/statistics & numerical data Pilot Projects Progesterone/*administration & dosage Prospective Studies Uterine Hemorrhage/*drug therapy/physiopathology
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 12:29
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