Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.

Details

Serval ID
serval:BIB_06B6E7F2FE41
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.
Journal
Journal of Diabetes Research
Author(s)
Brajkovic S., Ferdaoussi M., Pawlowski V., Ezanno H., Plaisance V., Zmuda E., Hai T., Annicotte J.S., Waeber G., Abderrahmani A.
ISSN
2314-6753 (Electronic)
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
2016
Pages
9158562
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Chronic intake of saturated free fatty acids is associated with diabetes and may contribute to the impairment of functional beta cell mass. Mitogen activated protein kinase 8 interacting protein 1 also called islet brain 1 (IB1) is a candidate gene for diabetes that is required for beta cell survival and glucose-induced insulin secretion (GSIS). In this study we investigated whether IB1 expression is required for preserving beta cell survival and function in response to palmitate. Chronic exposure of MIN6 and isolated rat islets cells to palmitate led to reduction of the IB1 mRNA and protein content. Diminution of IB1 mRNA and protein level relied on the inducible cAMP early repressor activity and proteasome-mediated degradation, respectively. Suppression of IB1 level mimicked the harmful effects of palmitate on the beta cell survival and GSIS. Conversely, ectopic expression of IB1 counteracted the deleterious effects of palmitate on the beta cell survival and insulin secretion. These findings highlight the importance in preserving the IB1 content for protecting beta cell against lipotoxicity in diabetes.
Pubmed
Web of science
Open Access
Yes
Create date
19/02/2016 18:09
Last modification date
20/08/2019 12:28
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