Cytokines et lèpre .

Details

Serval ID
serval:BIB_06AA5BC1FD25
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Cytokines et lèpre .
Journal
Acta Leprologica
Author(s)
Launois P.
ISSN
0001-5938 (Print)
ISSN-L
0001-5938
Publication state
Published
Issued date
1992
Volume
8
Number
1
Pages
5-10
Language
french
Notes
[Cytokines and leprosy]
Abstract
One of the functions expressed by the effectors of the immune system is the synthesis of cytokines, either in soluble form or associated with the membrane. Study of this communication network between the different compartments of the immune system can be conducted either in the blood (serum) of leprosy patients or directly in the infected tissues. The key to how the immune response will develop lies in the nature of the cytokines produced locally by the immune cells. For the characterization and detection of cytokines/lymphokines we may use either biological methods (bioassay), or antibody-based detection systems (RIA, Elisa, Elispot, immunocytochemistry using monoclonal antibodies), or techniques derived from molecular biology (Polymerase chain reaction-PCR, analysis of messenger RNA, and hybridization in situ). These various techniques, whose advantages and disadvantages are discussed, have demonstrated that locally, in the infected lesions, resistance and/or susceptibility to M. leprae infection correlates with differing cytokine secretion profiles.
Keywords
Biological Assay/standards, Cytokines/blood, Cytokines/genetics, Gene Expression, Humans, Immunoassay/standards, Leprosy/blood, Leprosy/genetics
Pubmed
Create date
28/01/2008 11:06
Last modification date
20/08/2019 12:28
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