The role of the TRAF-interacting protein in proliferation and differentiation.

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State: Public
Version: author
Serval ID
serval:BIB_06A0DE76C2D4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of the TRAF-interacting protein in proliferation and differentiation.
Journal
Experimental Dermatology
Author(s)
Chapard C., Hohl D., Huber M.
ISSN
1600-0625 (Electronic)
ISSN-L
0906-6705
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
21
Number
5
Pages
321-326
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Ubiquitination of proteins is a post-translational modification, which decides on the cellular fate of the protein. Addition of ubiquitin moieties to proteins is carried out by the sequential action of three enzymes: E1, ubiquitin-activating enzyme; E2, ubiquitin-conjugating enzyme; and E3, ubiquitin ligase. The TRAF-interacting protein (TRAIP, TRIP, RNF206) functions as Really Interesting New Gene (RING)-type E3 ubiquitin ligase, but its physiological substrates are not yet known. TRAIP was reported to interact with TRAF [tumor necrosis factor (TNF) receptor-associated factors] and the two tumor suppressors CYLD and Syk (spleen tyrosine kinase). Ectopically expressed TRAIP was shown to inhibit nuclear factor-kappa B (NF-κB) signalling. However, recent results suggested a role for TRAIP in biological processes other than NF-κB regulation. Knock-down of TRAIP in human epidermal keratinocytes repressed cellular proliferation and induced a block in the G1/S phase of the cell cycle without affecting NF-κB signalling. TRAIP is necessary for embryonal development as mutations affecting the Drosophila homologue of TRAIP are maternal effect-lethal mutants, and TRAIP knock-out mice die in utero because of aberrant regulation of cell proliferation and apoptosis. These findings underline the tight link between TRAIP and cell proliferation. In this review, we summarize the data on TRAIP and put them into a larger perspective regarding the role of TRAIP in the control of tissue homeostasis.
Keywords
Animals, Cell Differentiation/physiology, Cell Proliferation, Embryonic Development/physiology, Humans, Mice, Mice, Knockout, NF-kappa B/antagonists & inhibitors, Signal Transduction/physiology, Skin/cytology, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/genetics, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/physiology
Pubmed
Web of science
Open Access
Yes
Create date
12/05/2012 8:42
Last modification date
20/08/2019 12:28
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