Non oxidative fructose disposal is not inhibited by lipids in humans

Details

Serval ID
serval:BIB_069F268DD42A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Non oxidative fructose disposal is not inhibited by lipids in humans
Journal
Diabetes and Metabolism
Author(s)
Surmely  J. F., Paquot  N., Schneiter  P., Jequier  E., Temler  E., Tappy  L.
ISSN
1262-3636 (Print)
Publication state
Published
Issued date
09/1999
Volume
25
Number
3
Pages
233-40
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
Elevated free fatty acid concentrations are known to decrease insulin-mediated glucose uptake, glucose oxidation and glycogen synthesis. In order to determine whether free fatty acids inhibit glycogen synthesis at the level of liver cells, the effects of an infusion of lipids on carbohydrate metabolism were investigated in healthy subjects during a two-step (16.7 and 33.4 mumol/(kg.min) 13C-fructose infusion. Fructose infusion dose-dependently stimulated fructose (measured from 13CO2 production) and net carbohydrate oxidation (measured with indirect calorimetry). It also stimulated systemic 13C glucose appearance, indicating a dose-dependent stimulation of gluconeogenesis. Net glucose output (measured with 6,6 2H glucose) was however not altered. Lipid infusion significantly reduced fructose oxidation (measured from 13CO2 production) at both rates of fructose infusion, but did not alter plasma fructose or lactate concentrations, nor plasma 13C glucose appearance or net glucose production. Non oxidative fructose disposal was increased by 31% (p < 0.05) at the lowest, and by 18% (p < 0.01) at the highest infusion rate. Since nonoxidative fructose disposal corresponds mainly to liver glycogen deposition, these results suggest that lipid infusion increased hepatic glycogen synthesis, and hence that hepatic glycogen synthase is not inhibited by fatty acids.
Keywords
Adult Blood Glucose/metabolism Carbon Isotopes Deuterium/metabolism Energy Metabolism Female Fructose/administration & dosage/*metabolism Glucose/*metabolism Humans Infusions, Intravenous Kinetics Male Oxidation-Reduction
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 12:28
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