Comparison of Epi-LASIK and off-flap Epi-LASIK for the treatment of low and moderate myopia.

Details

Serval ID
serval:BIB_067EF0FCBC9C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of Epi-LASIK and off-flap Epi-LASIK for the treatment of low and moderate myopia.
Journal
Ophthalmology
Author(s)
Kalyvianaki M.I., Kymionis G.D., Kounis G.A., Panagopoulou S.I., Grentzelos M.A., Pallikaris I.G.
ISSN
1549-4713 (Electronic)
ISSN-L
0161-6420
Publication state
Published
Issued date
12/2008
Peer-reviewed
Oui
Volume
115
Number
12
Pages
2174-2180
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
To compare the early postoperative course and the 1-year clinical results of off-flap Epi-LASIK and Epi-LASIK for the treatment of low and moderate myopia.
Pilot double-masked, randomized, comparative study.
Fifty-six patients (112 myopic eyes).
Epithelium was separated in all eyes with the use of Centurion SES epikeratome (Norwood Abbey EyeCare, Vic, Australia). The first eye treated and surgical method in the first eye were randomized. One eye of each patient underwent standard Epi-LASIK, whereas in the contralateral eye, the epithelial sheet was not retained on the photoablated stroma (off-flap Epi-LASIK eyes). Mean preoperative spherical equivalent was -3.50+/-1.22 diopters (D; range, -1.75 to -6.37 D) in Epi-LASIK eyes and -3.61+/-1.22 D (range, -1.50 to -6.50 D) in off-flap Epi-LASIK eyes (P>0.05, paired Student t test). Excimer laser corneal ablation was performed using the Allegretto 200Hz (Wavelight Laser Technologie AG, Erlangen, Germany). Patients were followed up daily until the epithelial healing was complete and at 1, 3, 6, and 12 months.
Epithelial healing time, subjective pain score, and uncorrected visual acuity (UCVA) were evaluated during the first postoperative days. Uncorrected visual acuity, spherical equivalent refraction, best spectacle-corrected visual acuity, haze scores, and wavefront aberrations were recorded at all subsequent intervals.
Time of epithelial healing did not differ significantly in Epi-LASIK and off-flap Epi-LASIK eyes (4.76+/-0.84 days in Epi-LASIK eyes vs. 4.54+/-0.93 days in off-flap Epi-LASIK eyes). No significant difference in UCVA was found after the 2 techniques during the first postoperative days. Subjective pain score was lower in off-flap Epi-LASIK eyes at 2 postoperative hours, whereas no significant difference in pain scores was noted between the 2 techniques at the other intervals. There was no significant difference in spherical equivalent, line gain or loss, haze scores, and higher-order aberrations between Epi-LASIK and off-flap Epi-LASIK eyes at any interval. Uncorrected visual acuity was significantly better in Epi-LASIK eyes only at 6 months (-0.05+/-0.08 in Epi-LASIK eyes vs. 0.00+/-0.07 in off-flap Epi-LASIK eyes). Preoperative wavefront aberrations did not change significantly 1 year after either procedure.
Epi-LASIK and off-flap Epi-LASIK had equal visual and refractive results for the treatment of low and moderate myopia in this study.
Proprietary or commercial disclosure may be found after the references.
Keywords
Adolescent, Adult, Corneal Stroma/surgery, Double-Blind Method, Female, Humans, Keratomileusis, Laser In Situ/methods, Lasers, Excimer/therapeutic use, Male, Middle Aged, Myopia/classification, Myopia/surgery, Pain, Postoperative, Pilot Projects, Postoperative Complications, Surgical Flaps, Treatment Outcome, Visual Acuity/physiology, Wound Healing/physiology, Young Adult
Pubmed
Web of science
Create date
01/10/2019 16:56
Last modification date
06/10/2019 5:26
Usage data