Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma.

Details

Serval ID
serval:BIB_061E0A8E0299
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Statin use and peripheral blood progenitor cells mobilization in patients with multiple myeloma.
Journal
Clinical and Translational Oncology
Author(s)
Stravodimou A., Voutsadakis I.A.
ISSN
1699-3055 (Electronic)
ISSN-L
1699-048X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
16
Number
1
Pages
85-90
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
PURPOSE: Statins have beneficial effects in patients after myocardial infarction and at least part of the benefit results from mobilization of marrow endothelial progenitors to repopulate damaged myocardial tissues. This study examines if statins may have the same effect in mobilizing marrow progenitors to be harvested and subsequently used in high-dose chemotherapy with progenitor cell rescue in multiple myeloma.
METHODS: From 2006 to 2012, 86 patients with multiple myeloma were mobilized with the use of G-CSF and were retrospectively analyzed. Patients with other malignancies or mobilized with the use of chemotherapy or with plerixafor were excluded.
RESULTS: The median age of the patients was 60 years. 72 patients had received one line of chemotherapy and 14 patients two or more lines of chemotherapy. Twenty patients were taking statins at the time of the harvest while 66 patients were not. In the group of patients taking statins the success rate of first leukapheresis (obtaining the target number of 4 × 10(6) CD34+ cells/kg) was 85 % while in the group not taking statins this rate was 63.6 %. Despite the comparatively small number of patients this difference approached statistical significance (χ (2) = 0.07).
CONCLUSION: This retrospective analysis of 86 patients shows for the first time a possible benefit of statins for peripheral blood progenitor cells mobilization in patients with multiple myeloma. Larger studies would be required to clarify the issue. If their effectiveness is confirmed, statins could be a safe and cheaper addition to chemotherapy and plerixafor for peripheral hematopoietic stem cell mobilization.
Pubmed
Web of science
Create date
07/02/2014 20:46
Last modification date
20/08/2019 12:28
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