Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy

Details

Serval ID
serval:BIB_060EAC92EE6A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy
Journal
Radiat. Oncol.
Author(s)
Mein Stewart, Dokic Ivana, Klein Carmen, Tessonnier Thomas, Böhlen Till Tobias, Magro Guiseppe, Bauer Julia, Ferrari Alfredo, Parodi Katia, Haberer Thomas, Debus Jürgen, Abdollahi Amir, Mairani Andrea
ISSN
1748-717X
Publication state
Published
Issued date
12/2019
Volume
14
Number
1
Pages
123
Language
english
Abstract
Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated tumors like heavier ions, while simultaneously lessened particle fragmentation in distal healthy tissues as observed with lighter protons. Despite these biophysical advantages, raster-scanning 4He ion therapy remains poorly explored e.g., clinical translational is hampered by the lack of reliable and robust estimation of physical and radiobiological uncertainties. Therefore, prior to the upcoming 4He ion therapy program at the Heidelberg Ion-beam Therapy Center (HIT), we aimed to characterize the biophysical phenomena of 4He ion beams and various aspects of the associated models for clinical integration. Characterization of biological effect for 4He ion beams was performed in both homogenous and patient-like treatment scenarios using innovative models for estimation of relative biological effectiveness (RBE) in silico and their experimental validation using clonogenic cell survival as the gold-standard surrogate. Towards translation of RBE models in patients, the first GPU-based treatment planning system (non-commercial) for raster-scanning 4He ion beams was devised in-house (FRoG). Our data indicate clinically relevant uncertainty of ±5–10% across different model simulations, highlighting their distinct biological and computational methodologies. The in vitro surrogate for highly radio-resistant tissues presented large RBE variability and uncertainty within the clinical dose range. Existing phenomenological and mechanistic/biophysical models were successfully integrated and validated in both Monte Carlo and GPU-accelerated analytical platforms against in vitro experiments, and tested using pristine peaks and clinical fields in highly radio-resistant tissues where models exhibit the greatest RBE uncertainty. Together, these efforts mark an important step towards clinical translation of raster-scanning 4He ion beam therapy to the clinic.
Keywords
Radiotherapy, particle therapy, relative biological effectiveness, Oncology, correspondence, mairani, Cancer Research, andrea, de, department of radiation oncology, heidelberg, helium ions, Helium ions, hit, Imaging / Radiology, ion-beam therapy center, katia parodi and dr, med, Particle therapy, previous affiliation, prof, Relative biological e, thomas tessonnier, translational research, uni-heidelberg
Create date
15/03/2023 10:08
Last modification date
16/03/2023 7:48
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