Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A consensus paper by the European Myeloma Network and the Italian Society of Arterial Hypertension.
Details
Serval ID
serval:BIB_060BBCFF978B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A consensus paper by the European Myeloma Network and the Italian Society of Arterial Hypertension.
Journal
Journal of internal medicine
ISSN
1365-2796 (Electronic)
ISSN-L
0954-6820
Publication state
Published
Issued date
07/2019
Peer-reviewed
Oui
Volume
286
Number
1
Pages
63-74
Language
english
Notes
Publication types: Consensus Development Conference ; Journal Article ; Practice Guideline
Publication Status: ppublish
Publication Status: ppublish
Abstract
The novel proteasome inhibitor carfilzomib alone or in combination with other agents is already one of the standard therapies for relapsed and/or refractory multiple myeloma (MM) patients and produces impressive response rates in newly diagnosed MM as well. However, carfilzomib-related cardiovascular adverse events (CVAEs) - including hypertension (all grades: 12.2%; grade ≥3: 4.3%), heart failure (all grades: 4.1%; grade ≥3: 2.5%) and ischemic heart disease (all grades: 1.8%; grade ≥3: 0.8%) - may lead to treatment suspensions. At present, there are neither prospective studies nor expert consensus on the prevention, monitoring and treatment of CVAEs in myeloma patients treated with carfilzomib.
An expert panel of the European Myeloma Network in collaboration with the Italian Society of Arterial Hypertension and with the endorsement of the European Hematology Association aimed to provide recommendations to support health professionals in selecting the best management strategies for patients, considering the impact on outcome and the risk-benefit ratio of diagnostic and therapeutic tools, thereby achieving myeloma response with novel combination approaches whilst preventing CVAEs.
Patients scheduled to receive carfilzomib need a careful cardiovascular evaluation before treatment and an accurate follow-up during treatment.
A detailed clinical assessment before starting carfilzomib treatment is essential to identify patients at risk for CVAEs, and accurate monitoring of blood pressure and of early signs and symptoms suggestive of cardiac dysfunction remains pivotal to safely administer carfilzomib without treatment interruptions or dose reductions.
An expert panel of the European Myeloma Network in collaboration with the Italian Society of Arterial Hypertension and with the endorsement of the European Hematology Association aimed to provide recommendations to support health professionals in selecting the best management strategies for patients, considering the impact on outcome and the risk-benefit ratio of diagnostic and therapeutic tools, thereby achieving myeloma response with novel combination approaches whilst preventing CVAEs.
Patients scheduled to receive carfilzomib need a careful cardiovascular evaluation before treatment and an accurate follow-up during treatment.
A detailed clinical assessment before starting carfilzomib treatment is essential to identify patients at risk for CVAEs, and accurate monitoring of blood pressure and of early signs and symptoms suggestive of cardiac dysfunction remains pivotal to safely administer carfilzomib without treatment interruptions or dose reductions.
Keywords
Cardiovascular Diseases/chemically induced, Cardiovascular Diseases/diagnosis, Cardiovascular Diseases/prevention & control, Cardiovascular Diseases/therapy, Decision Trees, Humans, Monitoring, Physiologic, Multiple Myeloma/drug therapy, Oligopeptides/adverse effects, Oligopeptides/therapeutic use, adverse events, blood pressure monitoring, cardiovascular toxicity, carfilzomib, clinical assessment, multiple myeloma
Pubmed
Web of science
Create date
02/12/2024 16:49
Last modification date
04/12/2024 7:07