Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors.

Details

Serval ID
serval:BIB_060706490373
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors.
Journal
Traffic
Author(s)
Khalifeh D., Neveu E., Fasshauer D.
ISSN
1600-0854 (Electronic)
ISSN-L
1398-9219
Publication state
Published
Issued date
08/2022
Peer-reviewed
Oui
Volume
23
Number
8
Pages
414-425
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Many intracellular pathogens, such as bacteria and large viruses, enter eukaryotic cells via phagocytosis, then replicate and proliferate inside the host. To avoid degradation in the phagosomes, they have developed strategies to modify vesicle trafficking. Although several strategies of bacteria have been characterized, it is not clear whether viruses also interfere with the vesicle trafficking of the host. Recently, we came across SNARE proteins encoded in the genomes of several bacteria of the order Legionellales. These pathogenic bacteria may use SNAREs to interfere with vesicle trafficking, since SNARE proteins are the core machinery for vesicle fusion during transport. They assemble into membrane-bridging SNARE complexes that bring membranes together. We now have also discovered SNARE proteins in the genomes of diverse giant viruses. Our biochemical experiments showed that these proteins are able to form SNARE complexes. We also found other key trafficking factors that work together with SNAREs such as NSF, SM, and Rab proteins encoded in the genomes of giant viruses, suggesting that viruses can make use of a large genetic repertoire of trafficking factors. Most giant viruses possess different collections, suggesting that these factors entered the viral genome multiple times. In the future, the molecular role of these factors during viral infection need to be studied.
Keywords
Eukaryota/metabolism, Eukaryotic Cells/metabolism, Membrane Fusion, Phagosomes/metabolism, SNARE Proteins/metabolism, Eukaryota, Giant viruses, Mimivirus, Munc18 proteins, N-ethylmaleimide-sensitive factor, Ras protein, SNARE proteins, legionella, membrane trafficking
Pubmed
Web of science
Create date
21/06/2022 10:27
Last modification date
04/08/2022 6:38
Usage data