Striatal responsiveness to reward under threat-of-shock and working memory load: A preliminary study.

Details

Serval ID
serval:BIB_0602D6C6786F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Striatal responsiveness to reward under threat-of-shock and working memory load: A preliminary study.
Journal
Brain and behavior
Author(s)
Gaillard C., Guillod M., Ernst M., Torrisi S., Federspiel A., Schoebi D., Recabarren R.E., Ouyang X., Mueller-Pfeiffer C., Horsch A., Homan P., Wiest R., Hasler G., Martin-Soelch C.
ISSN
2162-3279 (Electronic)
Publication state
Published
Issued date
10/2019
Peer-reviewed
Oui
Volume
9
Number
10
Pages
e01397
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational and hedonic processes in healthy adults.
A reward task, involving stress with unpredictable mild electric shocks, was conducted in 23 healthy adults aged 20-37 (mean age: 24.7 ± 0.9; 14 females) during functional magnetic resonance imaging (fMRI). Manipulation included the use of (a) monetary reward for reinforcement, (b) threat-of-shock as the stressor, and (c) a spatial working memory task with two levels of difficulty (low and high load) for cognitive load. Reward-related activation was investigated in a priori three regions of interest, the nucleus accumbens (NAcc), caudate nucleus, and putamen.
During anticipation, threat-of-shock or cognitive load did not affect striatal responsiveness to reward. Anticipated reward increased activation in the ventral and dorsal striatum. During feedback delivery, both threat-of-shock and cognitive effort modulated striatal activation. Higher working memory load blunted NAcc responsiveness to reward delivery, while stress strengthened caudate nucleus reactivity regardless reinforcement or load.
These findings provide initial evidence that both stress and cognitive load modulate striatal responsiveness during feedback delivery but not during anticipation in healthy adults. Of clinical importance, sustained stress exposure might go along with dysregulated arousal, increasing therefore the risk for the development of maladaptive incentive-triggered motivation. This study brings new insight that might help to build a framework to understand common stress-related disorders, given that these psychiatric disorders involve disturbances of the reward system, cognitive deficits, and abnormal stress reactivity.
Keywords
Adult, Corpus Striatum/physiology, Electric Stimulation, Female, Humans, Magnetic Resonance Imaging/methods, Male, Memory, Short-Term/physiology, Motivation/physiology, Reward, Stress, Psychological/physiopathology, Young Adult, anticipation, delivery, fMRI, reward, stress, striatum, working memory
Pubmed
Web of science
Open Access
Yes
Create date
10/10/2019 16:31
Last modification date
19/06/2020 5:21
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