RNA polymerase III transcription as a disease factor.

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Ressource 1Download: Genes Dev.-2020-Yeganeh-865-82.pdf (1257.06 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_05D97F79A5F4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
RNA polymerase III transcription as a disease factor.
Journal
Genes & development
Author(s)
Yeganeh M., Hernandez N.
ISSN
1549-5477 (Electronic)
ISSN-L
0890-9369
Publication state
Published
Issued date
01/07/2020
Peer-reviewed
Oui
Volume
34
Number
13-14
Pages
865-882
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in eukaryotic cells, whose RNA products have well-defined functions in translation and other biological processes for some, and functions that remain to be defined for others. For all of them, however, new functions are being described. For example, Pol III products have been reported to regulate certain proteins such as protein kinase R (PKR) by direct association, to constitute the source of very short RNAs with regulatory roles in gene expression, or to control microRNA levels by sequestration. Consistent with these many functions, deregulation of Pol III transcribed genes is associated with a large variety of human disorders. Here we review different human diseases that have been linked to defects in the Pol III transcription apparatus or to Pol III products imbalance and discuss the possible underlying mechanisms.
Keywords
Alu, BC200, RMRP, RNA polymerase III, cancer, disease, leukodystrophy, nc886, tRNA, transcription
Pubmed
Open Access
Yes
Create date
08/07/2020 13:21
Last modification date
20/02/2021 7:21
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