Elevation de la tension arterielle lors de chirurgie sous garrot pneumatique: un mecanisme independant de la renine? [Elevation of arterial pressure during surgery with a pneumatic tourniquet: an independent action of renin?]

Details

Serval ID
serval:BIB_0565F1B2468D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Elevation de la tension arterielle lors de chirurgie sous garrot pneumatique: un mecanisme independant de la renine? [Elevation of arterial pressure during surgery with a pneumatic tourniquet: an independent action of renin?]
Journal
Canadian Journal of Anaesthesia
Author(s)
Magnusson  L., Rebagliati  M., Buchser  E.
ISSN
0832-610X (Print)
Publication state
Published
Issued date
07/1993
Volume
40
Number
7
Pages
596-600
Notes
Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: Jul
Abstract
The aim of this study was to evaluate the effectiveness of captopril for the prevention of the increase of arterial pressure during orthopaedic surgery requiring the application of lower limb tourniquets with balanced anaesthesia. Twenty consecutive patients were included in the study and were randomly divided into two groups. The first (n = 10) received 50 mg captopril orally together with the preanaesthetic medication, the second (n = 10) received a placebo at the same time. The different variables studied (arterial pressure, heart rate) were continuously measured. This study demonstrated that the pretreatment with captopril did not prevent an increase of the arterial pressure during the application of a tourniquet. The means of the systolic and diastolic arterial pressures at the end of the application of the tourniquet were 128/86 and 128/81 in the captopril group and the placebo group, respectively. This result shows that the renin-angiotensin system does not significantly contribute to the increase of the arterial pressure induced by a tourniquet.
Keywords
Adult Aged Anesthesia, Intravenous Blood Pressure/drug effects/*physiology Captopril/administration & dosage/*pharmacology Female Heart Rate/physiology Humans Hypertension/physiopathology Male Middle Aged Placebos Renin/*physiology Renin-Angiotensin System/drug effects/physiology *Tourniquets
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 10:51
Last modification date
20/08/2019 12:27
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