Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants.

Details

Serval ID
serval:BIB_05516E08DE14
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants.
Journal
Acta diabetologica
Author(s)
Eandi C.M., De Geronimo D., Giannini D., Polito M.S., Tosi G.M., Neri G., Le Mer Y., Varano M., Parravano M.
ISSN
1432-5233 (Electronic)
ISSN-L
0940-5429
Publication state
Published
Issued date
07/2020
Peer-reviewed
Oui
Volume
57
Number
7
Pages
867-874
Language
english
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Abstract
To evaluate the timing and spectral-domain optical coherence tomography (SD-OCT) features of diabetic macular oedema (DME) recurrence according to baseline OCT patterns in patients treated with dexamethasone implant (DEX-I).
This is a retrospective observational study (72 eyes/65 patients). Best-corrected visual acuity, timing of DME recurrence, and SD-OCT pattern [intraretinal cysts (IRC), IRC plus subretinal fluid (mixed), external limiting membrane (ELM), ellipsoid (IS/OS) layer integrity] were assessed at baseline and monthly until first DME recurrence.
Forty-two (58.3%) and 30 (41.6%) DME eyes had an IRC and mixed DME pattern at baseline, respectively. Twenty-four out of thirty mixed eyes (80%) relapsed without subretinal fluid. At baseline, mixed eyes showed similar changes in ELM and IS/OS (60 and 76.6% of eyes, respectively) versus IRC eyes (42.8 and 80.9% of eyes). After DME recurrence, more mixed eyes at baseline showed ELM and IS/OS changes (63.3 and 86.6%) than IRC eyes (50 and 76.2%). 33.3% of mixed eyes had DME recurrence at ≥ 6 months from first DEX-I implant versus 19% of IRC eyes.
Mixed DME eyes were treated with DEX-I relapse later and more frequently without subretinal fluid than IRC eyes. SD-OCT characteristics of different DME patterns at baseline can predict morphological features and timing of DME recurrence.
Keywords
Aged, Dexamethasone/administration & dosage, Diabetic Retinopathy/diagnosis, Diabetic Retinopathy/drug therapy, Diabetic Retinopathy/pathology, Drug Implants/administration & dosage, Female, Fluorescein Angiography, Humans, Intravitreal Injections, Macular Edema/diagnosis, Macular Edema/drug therapy, Macular Edema/pathology, Male, Middle Aged, Organ Size/drug effects, Prognosis, Recurrence, Retina/diagnostic imaging, Retina/drug effects, Retina/pathology, Retina/physiopathology, Retrospective Studies, Time Factors, Tomography, Optical Coherence/methods, Treatment Outcome, Visual Acuity/drug effects, Baseline characteristics, Dexamethasone implant (DEX-I), Diabetic macular oedema, Intravitreal treatment, Spectral-domain optical coherence tomography
Pubmed
Web of science
Open Access
Yes
Create date
05/03/2020 16:36
Last modification date
13/03/2021 7:22
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