Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model.

Details

Serval ID
serval:BIB_053621095554
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model.
Journal
Blood
Author(s)
Tritschler T., Méan M., Limacher A., Rodondi N., Aujesky D.
ISSN
1528-0020 (Electronic)
ISSN-L
0006-4971
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
126
Number
16
Pages
1949-1951
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The updated Vienna Prediction Model for estimating recurrence risk after an unprovoked venous thromboembolism (VTE) has been developed to identify individuals at low risk for VTE recurrence in whom anticoagulation (AC) therapy may be stopped after 3 months. We externally validated the accuracy of the model to predict recurrent VTE in a prospective multicenter cohort of 156 patients aged ≥65 years with acute symptomatic unprovoked VTE who had received 3 to 12 months of AC. Patients with a predicted 12-month risk within the lowest quartile based on the updated Vienna Prediction Model were classified as low risk. The risk of recurrent VTE did not differ between low- vs higher-risk patients at 12 months (13% vs 10%; P = .77) and 24 months (15% vs 17%; P = 1.0). The area under the receiver operating characteristic curve for predicting VTE recurrence was 0.39 (95% confidence interval [CI], 0.25-0.52) at 12 months and 0.43 (95% CI, 0.31-0.54) at 24 months. In conclusion, in elderly patients with unprovoked VTE who have stopped AC, the updated Vienna Prediction Model does not discriminate between patients who develop recurrent VTE and those who do not. This study was registered at www.clinicaltrials.gov as #NCT00973596.
Pubmed
Web of science
Open Access
Yes
Create date
03/01/2016 16:45
Last modification date
21/10/2019 20:54
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