Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8+ T-cell responses to the tumor-specific antigen NY-ESO-1.

Details

Serval ID
serval:BIB_051609610ADD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8+ T-cell responses to the tumor-specific antigen NY-ESO-1.
Journal
Journal of Immunotherapy
Author(s)
Le Gal F.A., Ayyoub M., Dutoit V., Widmer V., Jäger E., Cerottini J.C., Dietrich P.Y., Valmori D.
ISSN
1524-9557
Publication state
Published
Issued date
06/2005
Peer-reviewed
Oui
Volume
28
Number
3
Pages
252-257
Language
english
Abstract
Spontaneous immune responses to the cancer testis antigen NY-ESO-1 are frequently found in cancer patients bearing antigen-expressing tumors. In HLA-A2-expressing patients, naturally elicited NY-ESO-1-specific, tumor-reactive cytotoxic T lymphocytes (CTLs) are mostly directed against an immunodominant epitope corresponding to peptide NY-ESO-1 157-165. NY-ESO-1-specific CTLs can also be induced by synthetic peptide vaccines, but they are heterogeneous in terms of functional avidity and tumor reactivity. The authors investigated the structural bases of this phenomenon by analyzing the TCR features of natural and vaccine-induced NY-ESO-1-specific CTLs. The results indicate that CTLs from the two groups exhibit highly structurally conserved but distinct TCR features, suggesting that the synthetic peptides used for vaccination may fail to faithfully mimic the naturally processed antigen. Together, the results of this study underline the strength of TCR molecular monitoring and will be instrumental for the development and monitoring of vaccines aimed at eliciting CTLs with high tumor reactivity.
Keywords
Amino Acid Sequence, Antigens, Neoplasm/immunology, Cancer Vaccines/immunology, Humans, Molecular Sequence Data, Neoplasm Proteins/immunology, Peptide Fragments/immunology, Receptors, Antigen, T-Cell/chemistry, T-Lymphocytes, Cytotoxic/immunology, Vaccines, Subunit/immunology
Pubmed
Web of science
Create date
28/01/2008 11:13
Last modification date
20/08/2019 12:26
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