SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_05087FA7722D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
Journal
Human Molecular Genetics
Author(s)
Ramirez A., van der Flier W.M., Herold C., Ramonet D., Heilmann S., Lewczuk P., Popp J., Lacour A., Drichel D., Louwersheimer E., Kummer M.P., Cruchaga C., Hoffmann P., Teunissen C., Holstege H., Kornhuber J., Peters O., Naj A.C., Chouraki V., Bellenguez C., Gerrish A., Heun R., Heun R., Frölich L., Hüll M., Buscemi L., Herms S., Kölsch H., Scheltens P., Breteler M.M., Rüther E., Wiltfang J., Goate A., Jessen F., Maier W., Heneka M.T., Becker T., Nöthen M.M.
Working group(s)
International Genomics of Alzheimer's Project (IGAP), Alzheimer's Disease Neuroimaging Initiative (ADNI)
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
23
Number
24
Pages
6644-6658
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Cerebrospinal fluid amyloid-beta 1-42 (Aβ1-42) and phosphorylated Tau at position 181 (pTau181) are biomarkers of Alzheimer's disease (AD). We performed an analysis and meta-analysis of genome-wide association study data on Aβ1-42 and pTau181 in AD dementia patients followed by independent replication. An association was found between Aβ1-42 level and a single-nucleotide polymorphism in SUCLG2 (rs62256378) (P = 2.5×10(-12)). An interaction between APOE genotype and rs62256378 was detected (P = 9.5 × 10(-5)), with the strongest effect being observed in APOE-ε4 noncarriers. Clinically, rs62256378 was associated with rate of cognitive decline in AD dementia patients (P = 3.1 × 10(-3)). Functional microglia experiments showed that SUCLG2 was involved in clearance of Aβ1-42.
Pubmed
Web of science
Open Access
Yes
Create date
24/07/2014 18:41
Last modification date
28/09/2019 6:08
Usage data