Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Details

Serval ID
serval:BIB_04F400495E25
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?
Journal
Neural Regeneration Research
Author(s)
de Luca A.C., Lacour S.P., Raffoul W., di Summa P.G.
ISSN
1673-5374 (Print)
ISSN-L
1673-5374
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
9
Number
22
Pages
1943-1948
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative to repairing peripheral nerve. They aim at confining the nerve environment throughout the regeneration process, and providing guidance to axon outgrowth. Biocompatible materials have been carefully designed to reduce inflammation and scar tissue formation, but modifications of the inner lumen are still required in order to optimise the scaffolds. Biomicking the native neural tissue with extracellular matrix fillers or coatings showed great promises in repairing longer gaps and extending cell survival. In addition, extracellular matrix molecules provide a platform to further bind growth factors that can be released in the system over time. Alternatively, conduit fillers can be used for cell transplantation at the injury site, reducing the lag time required for endogenous Schwann cells to proliferate and take part in the regeneration process. This review provides an overview on the importance of extracellular matrix molecules in peripheral nerve repair.
Pubmed
Web of science
Open Access
Yes
Create date
08/03/2015 11:00
Last modification date
20/08/2019 13:26
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