Commissioning of an ultra-high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols.

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Serval ID
serval:BIB_04A0655121E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Commissioning of an ultra-high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols.
Journal
Medical physics
Author(s)
Moeckli R., Gonçalves Jorge P., Grilj V., Oesterle R., Cherbuin N., Bourhis J., Vozenin M.C., Germond J.F., Bochud F., Bailat C.
ISSN
2473-4209 (Electronic)
ISSN-L
0094-2405
Publication state
Published
Issued date
06/2021
Peer-reviewed
Oui
Volume
48
Number
6
Pages
3134-3142
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To present the acceptance and the commissioning, to define the reference dose, and to prepare the reference data for a quality assessment (QA) program of an ultra-high dose rate (UHDR) electron device in order to validate it for preclinical animal FLASH radiotherapy (FLASH RT) experiments and for FLASH RT clinical human protocols.
The Mobetron <sup>®</sup> device was evaluated with electron beams of 9 MeV in conventional (CONV) mode and of 6 and 9 MeV in UHDR mode (nominal energy). The acceptance was performed according to the acceptance protocol of the company. The commissioning consisted of determining the short- and long-term stability of the device, the measurement of percent depth dose curves (PDDs) and profiles at two different positions (with two different dose per pulse regimen) and for different collimator sizes, and the evaluation of the variability of these parameters when changing the pulse width and pulse repetition frequency. Measurements were performed using a redundant and validated dosimetric strategy with alanine and radiochromic films, as well as Advanced Markus ionization chamber for some measurements.
The acceptance tests were all within the tolerances of the company's acceptance protocol. The linearity with pulse width was within 1.5% in all cases. The pulse repetition frequency did not affect the delivered dose more than 2% in all cases but 90 Hz, for which the larger difference was 3.8%. The reference dosimetry showed a good agreement within the alanine and films with variations of 2.2% or less. The short-term (resp. long-term) stability was less than 1.0% (resp. 1.8%) and was the same in both CONV and UHDR modes. PDDs, profiles, and reference dosimetry were measured at two positions, providing data for two specific dose rates (about 9 Gy/pulse and 3 Gy/pulse). Maximal beam size was 4 and 6 cm at 90% isodose in the two positions tested. There was no difference between CONV and UHDR mode in the beam characteristics tested.
The device is commissioned for FLASH RT preclinical biological experiments as well as FLASH RT clinical human protocols.
Keywords
Animal Experimentation, Animals, Clinical Protocols, Electrons, Humans, Particle Accelerators, Radiometry, Radiotherapy Dosage, FLASH, clinical transfer, commissioning, ultra-high dose rate
Pubmed
Web of science
Open Access
Yes
Create date
26/04/2021 11:14
Last modification date
13/10/2021 5:42
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